english.prescrire.org > Prescrire International > N°106 - April 2010

n°106

April 2010

Issue Contents
Editorial

Free  Clinical research: for whose benefit?

p.52
Explanatory versus pragmatic trials

New Products


Ulipristal (postcoital contraception) (New Drug)

p.53-55
No better than levonorgestrel

Rituximab (chronic lymphoid leukaemia) (New Indications)

p.56-58
No decisive advantage

Japanese encephalitis vaccine (New Drug)

p.59-61
Useful for selected adult travellers

Oral alitretinoin (severe chronic hand eczema)(New Drug)

p.62-63
Too risky

Zoledronic acid once-yearly (corticosteroid-induced osteoporosis) (New Indication)

p.63
No advantage

Aliskiren + hydrochlorothiazide (hypertension) (New Combination)

p.64
No evidence of benefits on hard endpoints

Trolamine over-the-counter (OTC switch)

p.64
Better emollients are available

Estradiol + dienogest (oral contraception) (New Combination)

p.65-67
No advantage

INN common stem: -gest-

p.67

Adverse Effects


Digoxin: serious drug interactions

p.68-70
Digoxin assay and clinical monitoring

Free  Telithromycin: visual disorders

p.71
Harms outweigh benefits

Varicella, herpes zoster and nonsteroidal anti-inflammatory drugs: serious cutaneous complications

p.72-73
Use paracetamol instead

Tendon disorders due to statins

p.73
The first year of therapy is crucial

Trimetazidine: new French pharmacovigilance data

p.74
More harms than benefits

H1N1 influenza vaccines: reassuring early reports

p.74
Updates from regulators and WHO

Cefaclor: serum sickness (again)

p.75
Use the drug sparingly

Oseltamivir: beware neuropsychological effects in young patients

p.75
Confirmation of adverse effect profile

Omalizumab: cardiac adverse effects

p.75
Unfavourable risk-benefit balance

Sitagliptin: too many cases of pancreatitis

p.75
There are safer options

Reviews


From Prescrire's 2009 drug review: A recap of which new drugs to avoid

p.76-80
The drugs that Prescrire rated “nothing new” or "unacceptable” in 2009, listed by category of conditions treated

Diagnosis of depression in children and adolescents

p.81-83
Clinical pointers to a difficult diagnosis

23-valent pneumococcal polyoside vaccination

p.84
Efficacy not yet demonstrated

Outlook


Free  2009 Prescrire Awards

p.85-88
Many novelties exposing patients to unjustified harms

Free  2009 Prescrire Drug Awards

p.86

Free  2009 Prescrire Packaging Awards

p.87

Free  2009 Prescrire Information Awards

p.88

Free  A look back at 2009: one step forward, two steps back

p.89-94
Nearly 20% of new drugs authorised in France rated "not acceptable"

Free  The 2010 "Prescrire Encounters" "For accessible quality healthcare" Brussels May 2010

p.96

Masthead


Free  Masthead

p.50

The complete contents of 
this issue of Prescrire International
are available for download by
Prescrire International subscribers.
Certain texts are also available to
non-subscribers for free download,
as indicated. 

 

Subscribe