english.prescrire.org > Prescrire International > N°130 - September 2012

n°130

September 2012

Issue Contents
Editorial

Free  An example to us all

p.200
A patient group raises awareness about Lyell and Stevens-Johnson syndromes

New Products


Apixaban (New Drug)

p.201-204
After hip or knee replacement: LMWH remains the standard treatment

Apixaban in other situations?

p.203

Denosumab and bone metastases (New Indication)

p.204-206
No better than a bisphosphonate

INN common stem: -gliptin

p.206

Ranibizumab and retinal vein occlusion (New Indication)

p.207
Too many outstanding questions

HPV 6,11,16,18 vaccine in men (New Indication)

p.208
Inadequate assessment

Phentermine: an appetite-suppressant amphetamine classified as a narcotic in France (Regulation)

p.209
Is a combination with topiramate on the horizon?

Adverse Effects


Proton pump inhibitors: bacterial pneumonia

p.210-212
Mostly at initiation of therapy

Intestinal alpha-glucosidase inhibitors: abdominal gas cysts

p.212-213
Acarbose and miglitol should not be used

Doripenem: excess mortality

p.214
The imipenem + cilastatin combination is safer

Ursodeoxycholic acid: increased mortality

p.214
Increased doubts about its harm-benefit balance

Cosmetic silicone injections: respiratory failure

p.214
Disproportionate adverse effects

Bortezomib: 3 deaths following intrathecal injection

p.214
Wrong route of administration

Reviews


PSA-based screening for prostate cancer

p.215-217
Too many adverse effects

Yaws, a non-venereal treponemal infection

p.217-219
Still endemic in some parts of the world

Bejel and Pinta: two other non-venereal treponematoses

p.219

Outlook


Free  Management of serious adverse drug reactions: proposals from a victims' organisation

p.220-223
Challenging the "risk-benefit ratio"

Free  The seven principles upheld by Amalyste

p.221

Free  Lyell and Stevens-Johnson syndromes

p.221

Free  The 10 key measures proposed by Amalyste (excerpts)

p.222

Free  Medical devices: marketing authorisations are needed

p.223
European regulation is inadequate

Masthead


Free  Masthead

p.198

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