english.prescrire.org > Prescrire International > N°140 - July 2013

n°140

July 2013

Issue Contents
Editorial

Free  The gamble

p.172
Ask the right questions before deciding on a treatment

New Products


Midazolam oral transmucosal route (Paediatrics)

p.173-177
An alternative to rectal diazepam for some children

Midazolam and EU Paediatric Use Marketing Authorisation: the minimum to meet regulatory requirements

p.176

INN common stem: -rozole

p.177

Emtricitabine + tenofovir to prevent HIV transmission (US Approval)

p.178-181
More evaluation needed

Risk-taking

p.181

Adverse Effects


Tranexamic acid and thrombosis

p.182-183
Harm-benefit balance differs according to bleeding severity

Free  Quetiapine and cardiac muscle disorders

p.184
Stop the drug if heart failure signs develop

Exposure to benfluorex: left heart valve disease very common

p.185
Strong evidence

Methylphenidate: trismus

p.185
Watch out for dystonia

SSRI antidepressants: brain haemorrhage

p.185
A 1.5-fold increase in the risk

Reviews


Do not use drugs to prevent onset of lactation

p.186-188
Relieve the discomfort and wait

Prescrire's advice

p.188
Do not use drugs to prevent lactation after delivery

Trauma and severe bleeding

p.189-190
Tranexamic acid within one hour to reduce mortality

Hepatitis C and interferon: fewer cases of liver cancer

p.191
More effective when viral load is undetectable

Outlook


Prescribe, but also know how to "deprescribe"

p.192
Eliminate unnecessary or harmful prescriptions

Free  Meals: a very effective gift

p.193
Accepting food is no trivial matter

Medical students' and junior doctors' attitudes to drug companies: a survey conducted in Lyon University Hospital, France

p.194
Medical schools must train students to be sceptical

Junior doctors' attitudes towards drug companies

p.195
Inadequate training about conflicts of interest

Masthead


Free  Masthead

p.170

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