english.prescrire.org > Prescrire International > N°166 - December 2015

n°166

December 2015

Issue Contents
Editorial

Free  The stock market, first served

p.284
Regulatory scrutiny should come first

New Products


Ledipasvir + sofosbuvir (Harvoni°)

p.285-289
A therapeutic advance in genotype 1 hepatitis C virus infection, despite uncertainties

Optimal HCV combination therapy?

p.288
Editors’ opinion

Daclatasvir (Daklinza°)

p.290
In chronic HCV genotype 3 or 4 infection

INN common stem: -asvir

p.290

Free  Misoprostol vaginal (Misodel°)

p.291
Riskier than dinoprostone for inducing labour

Adverse Effects


Cardiac adverse effects of nicotine replacement therapy

p.292-293
Palpitations, rarely serious cardiac disorders

Agomelatine: to be avoided, with or without a "patient booklet"

p.294
Risk of liver injury

Sofosbuvir + amiodarone: bradycardia and conduction disturbances

p.294-295
Suspected adverse reactions to new antivirals should be reported

Radionuclide myocardial perfusion imaging: cerebrovascular events and seizures

p.295
Diagnostic agents can have serious adverse effects

Aliskiren: hyponatraemia

p.295
This antihypertensive has an unfavourable harm-benefit balance

Donepezil: rhabdomyolysis and neuroleptic malignant syndrome

p.295
Potentially fatal

Reviews


Gastro-oesophageal reflux during pregnancy

p.296-299

Domperidone: do not use during pregnancy

p.298

Alcohol withdrawal syndrome: preventive measures

p.300-301

Parkinson's disease: fewer treatment withdrawals with levodopa

p.302
Interim trial results favour levodopa in newly diagnosed disease

Outlook


Comparative advantages of new drugs: French authorities are not sufficiently demanding

p.303-307

Free  FDA sanctions for misconduct in clinical trials; results published as if nothing were amiss

p.307
Publication journals fail to take violations into account

Masthead


Free  Masthead

p.282

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