english.prescrire.org > Prescrire International > N°168 - February 2016

n°168

February 2016

Issue Contents
Editorial

Free  Fight inertia!

p.32
Massive quantities of oseltamivir have been sold, despite a lack of evidence about its efficacy

New Products


Ospemifene (Senshio°)

p.33
More dangerous than helpful for women with postmenopausal vulvovaginal disorders

Unexpected benefit

p.34
Editors' opinion

Teduglutide (Revestive°)

p.34-35
For patients requiring permanent parenteral nutrition for short bowel syndrome

INN common stem: -navir

p.35

Denosumab (Prolia°) and male osteoporosis

p.36
Do not use in men (or in women)

Sorafenib (Nexavar°) and differentiated thyroid cancer

p.37
Toxic, and no proof of improved survival

Pasireotide (Signifor°) in acromegaly

p.38-39
After treatment failure: better than pegvisomant

Paracetamol + opium (Izalgi°) higher-dose for oral administration

p.39
A poor choice for analgesia

Insulin lispro (Humalog KwikPen°) double concentration 200 units/ml

p.40
Risk of confusion

Adverse Effects


Thiocolchicoside: review of adverse effects

p.41-43
No justification to use this drug

Thiocolchicoside: closely related to colchicine

p.42

Bismuth: more cases of encephalopathy

p.43
Expected toxicity

Tramadol: respiratory depression in a child

p.44
Overdose due to ultrarapid CYP2D6 metabolism

Tramadol: hypoglycaemia

p.44
Patients should be warned about the risk

Tramadol: hyponatraemia

p.44
Increased risk of hospital admission

Reviews


"Weak" opioid analgesics

p.45-51
Codeine, dihydrocodeine and tramadol: no less risky than morphine

Complex analgesic actions of opioids

p.47

Pregnancy: morphine, or sometimes buprenorphine, when paracetamol is ineffective

p.49

Influenza vaccination during pregnancy

p.51
Partial protection of mothers and infants

Outlook


Oseltamivir and influenza: still no robust data

p.52-55
No reason to recommend its widespread use

Oseltamivir for influenza, from birth: no more useful than in adults

p.53

Free  Oseltamivir: over 15 years of data retention and systematic stonewalling

p.55

Masthead


Free  Masthead

p.30

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