n°169

March 2016

Issue Contents
Editorial

Free  No more denial

p.60
Helping victims of drug-induced harms

New Products


Siltuximab (Sylvant°)

p.61-64
Castleman's disease: good symptomatic efficacy in some patients

Ketoconazole and endogenous Cushing's syndrome

p.65-66
Effective but tricky to use

INN common stem: -lisib

p.66

Botulinum toxin type A (Botox°) and idiopathic overactive bladder

p.67
For some severely affected patients

Adverse Effects


Quetiapine: misuse and abuse

p.68
Prescribers and pharmacists should be aware of the problem

Gliflozins: ketoacidosis

p.68
Mostly in type 2 diabetes

Extravasation of infused drugs: tissue damage, and not only with cancer drugs

p.69
Monitoring infusions is key

Epidural corticosteroid injections: serious neurological disorders

p.69
Unfavourable harm-benefit balance

Imatinib: muscle pain suggestive of a withdrawal syndrome

p.70
An unexpected adverse effect

Optic neuritis with TNF alpha antagonists

p.70
Visual disturbances are warning symptoms

Free  Drug-induced non-immune-mediated angioedema

p.71
ACE inhibitors are the most commonly implicated

Free  Noscapine: angioedema

p.71
Opioids can trigger angioedema

Free  Racecadotril + ACE inhibitors: angioedema

p.71
A combination that is best avoided

Tendon disorders with ofloxacin ear drops

p.72
Bear in mind the risk of systemic absorption

BCG Vaccine SSI°: numerous errors

p.72
Packaging needs improvement

Isotretinoin: anal fissure

p.72
A documented reaction

Reviews


Asthma

p.73-76
A summary of first-choice treatments

COPD: benefits of exercise training

p.76-77
Improvements in quality of life

Outlook


Free  2015 Prescrire Drug Awards

p.78-79

Free  The Prescrire Awards for 2015

p.78-81

Free  2015 Prescrire Packaging Awards

p.80-81

Free  2015 Prescrire Information Awards

p.81

Drug approval: clinical evidence often inadequate

p.82
In the USA as in the EU

Pesticides: a toxic issue

p.83
Industry opposed the ban on 3 neonicotinoid pesticides in the EU

Masthead


Free  Masthead

p.58

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