english.prescrire.org > Prescrire International > N°188 - December 2017

n°188

December 2017

Issue Contents
Editorial

Free  From mother to child

p.283

New Products


Ivacaftor (Kalydeco°) and cystic fibrosis

p.285-286
Uncertain harm-benefit balance

Ivacaftor + lumacaftor (Orkambi°) and cystic fibrosis

p.287-289
A harm-benefit balance that requires further investigation

Bevacizumab (Avastin°) for first-line treatment of certain types of lung cancer

p.289
It does not prolong survival but it exposes to more adverse effects

Daratumumab (Darzalex°) monotherapy in relapsed and refractory multiple myeloma

p.290-291
No evidence of efficacy

Brivaracetam (Briviact°) and partial seizures

p.292-293
A commercial ploy with a levetiracetam "me-too"

INN Common stem: -verine, -verium

p.293

Adverse Effects


Free  Valproic acid during pregnancy: assessment of malformations in France

p.294

Short-term corticosteroid treatment: fractures, thrombosis and infections

p.295

Apremilast: suicide risk

p.295

Chlorhexidine: anaphylaxis following skin application

p.296

Quinine and cramps: increased mortality

p.296

Reviews


Moderate intensity nociceptive pain in adults

p.297-300

Type 2 diabetes

p.300-301
Prevention through dietary modification and physical activity

Outlook


Making rational choices about drug treatment while breast-feeding

p.302-306

Inset. Breast-feeding and drugs: sources of information

p.304

Induction of labour: still inadequate provision of information, and women's consent not always obtained

p.306-307

Letters to Prescrire's editors: domperidone and sudden cardiac death

p.307

Masthead


Free  Masthead

p.282

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