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n°39

February 1999

Prescrire International

Issue Contents

Editorial
Regulatory measures in the hot seat	p.2

Marketing Authorisations
Topiramate: helpful in refractory partial epilepsy	p.3-5


Modafinil: confirmed efficacy in narcolepsy	p.5-7


Valaciclovir in genital herpes: simpler administration	p.8-9


Naltrexone: transient preventive efficacy on alcoholic relapse	p.9-11


Fexofenadine: terfenadine, without cardiotoxicity	p.11-13


Erythromycin and gastroparesis? uncertain efficacy for a poorly defined disorder	p.13-15


Mysterious gastroparesis	p.15


Tacrine: an outdated drug to be discarded	p.16-18


Citalopram, no advantage	p.18-19

Adverse Effects
Gallstones containing dipyridamole	p.20


Drug bezoars	p.20-21


Nephrolithiasis on indinavir	p.22


Drug-induced hiccups	p.23

Reviews
Recommendations for antiretroviral therapy during pregnancy	p.24-28


Prevention of mother-to-child HIV transmission: epidemiological studies	p.25


Toxicity of antiretroviral drugs in pregnancy: limited data	p.26


Natural history of mother-to-child HIV transmission	p.28


Quinolones and pregnancy: worrying animal findings, few clinical data	p.29-31

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n°39

February 1999

Prescrire International

Issue Contents

Marketing Authorisations

Adverse Effects

Reviews