english.prescrire.org > Prescrire International > N°64 - April 2003

n°64

April 2003

Issue Contents
Editorial

Transparency: the 5th dimension of drug evaluation

p.42

New Products


Serogroup C meningococcal conjugate vaccines: effective from age two months

p.43-46

Linezolid in severe Gram-positive infections

p.46-48

Imatinib for chronic myeloid leukaemia: further assessment required

p.49-52

Levetiracetam: for some patients with refractory epilepsy

p.53-54

Drotrecogin alfa: for some cases of severe sepsis?

p.55-57

The exemplary story of HA-1A monoclonal antibodies in severe sepsis

p.56

Atosiban: a tocolytic agent with no benefits for neonates

p.58

Letrozole, first-line indication: too many unknowns

p.58

Transdermal estradiol-levonorgestrel combination: too risky for menopause replacement therapy

p.58

Adverse Effects


Cutaneous ulceration with methotrexate

p.59-60

Zolpidem: now classified as a psychotropic at risk of abuse

p.60

Myopia and glaucoma with topiramate

p.61

Parkinsonian syndrome and calcium channel blockers

p.62

Preventing dental caries with fluoride: risk of overdose

p.63

Sibutramine: prescribing restrictions in France

p.63

Risperidone and stroke

p.63

Interactions between amiodarone and vitamin K antagonists

p.64

Fatal anaphylactic shock caused by lepirudin

p.64

Drug-induced bronchospasm

p.64

Eye problems with isotretinoin

p.64

Reviews


Postmenopausal hormone therapy: cardiovascular risks

p.65-69

Nasal polyps in adults: nasal steroids have only moderate efficacy

p.70

Chronic myeloid leukaemia: treatment is often insatisfactory

p.70

Prions: from sheep to cows

p.70

Tubal sterilisation

p.70

Outlook


Health consequences of the Chernobyl accident in France: persistent secrecy

p.71-72

Review of pharmaceutical legislation in Europe - Update, 31 December 2002

p.72

2002 Prescrire Awards

p.73

A review of new drugs and indications in 2002. Financial speculation or better patient care ?

p.74-77

Appetite suppressants: a revealing European Court decision

p.78-79

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