english.prescrire.org > Prescrire International > N°125 - March 2012

n°125

March 2012

Issue Contents
Editorial

Free  Unfinished business

p.60
France's new drug law does not go far enough

New Products


Retigabine (New Drug)

p.61
Fewer drug interactions

Rituximab in maintenance therapy for follicular lymphoma (New Indication)

p.62-63
No better than watchful waiting

Rituximab maintenance therapy of relapsed or refractory follicular lymphoma, with longer follow-up: no proven impact on survival

p.63

Bendamustine (New Drug)

p.64-65
Inadequate or outdated data

Ranibizumab and diabetic macular oedema (New Indication)

p.66
After laser therapy

INN common stem: -mustine

p.67

Adverse Effects


Free  In France, healthcare products are involved in about half of all serious adverse events related to healthcare

p.68
Mostly drugs

NSAIDs, corticosteroids and atrial fibrillation?

p.69-70
Weigh up the cons

Mephenesin: anaphylactic shock and acute generalised exanthematous pustulosis

p.70
Best to avoid using

Perinatal lopinavir + ritonavir: adrenal insufficiency

p.71
In neonates

Orlistat: hepatitis and oxalate nephropathy

p.71
Harms greater than benefits

Hypoglycaemia due to tramadol

p.71
Codeine a bit safer

Tramadol withdrawal symptoms in infants exposed in utero

p.71-72
Do not use during pregnancy

Thalidomide and lenalidomide: overview of the French pharmacovigilance database

p.72
Different toxicity profiles

Strontium ranelate: too many adverse effects (continued)

p.72
Do not use

Fluconazole: teratogenicity

p.72
FDA warning

Reviews


Bleeding from ruptured oesophageal varices

p.73-77
Propranolol for primary prevention

Oesophageal varices: a complication of portal hypertension

p.75

Prescrire's advice

p.77
Prevention of variceal bleeding

Outlook


Free  2011: Prescrire Awards

p.78-82

Free  2011 Prescrire Drug Awards

p.79

Free  2011 Prescrire Packaging Awards

p.80-81

Free  2011 Prescrire Information Awards

p.82

Free  Back cover Research financed independently of drug companies: a timely debate

p.84

Masthead


Free  Masthead

p.58

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