english.prescrire.org > Prescrire International > N°193 - May 2018

n°193

May 2018

Issue Contents
Editorial

Free  New cancer drugs: poorly evaluated, not very effective

p.115

New Products


Arsenic trioxide (Trisenox°) and acute promyelo­cytic leukaemia

p.117-118
First-line choice for patients at low or intermediate risk of relapse

Elotuzumab (Empliciti°) combination therapy for relapsed or refractory multiple myeloma

p.119-120
No proven therapeutic advance at this point

Blinatumomab (Blincyto°) and acute lymphoblastic leukaemia in adults

p.121-122
May offer a greater chance of receiving a transplant, but many severe adverse effects

INN Common stem: -nidazole

p.122

Dabrafenib (Tafinlar°) and trametinib (Mekinist°) combined for certain types of lung cancer

p.123
No proven impact on survival

Lacosamide (Vimpat°) monotherapy and focal epilepsy

p.124-125
No better than existing alternatives

Adverse Effects


Metopimazine: cardiac disorders

p.126-129

Inset. Too many patients exposed to metopimazine in France

p.127

Inset. Managing nausea and vomiting caused by gastroenteritis

p.128

Ketoprofen gel: serious photosensitivity reactions once again

p.129

Free  In utero exposure to diethylstilbestrol (DES): psychiatric disorders

p.130

Acid-based wart treatments: burns and sequelae

p.131-132

Oxetorone: chronic diarrhoea

p.132

Reviews


Herpes zoster during pregnancy

p.133-135
Aciclovir when an antiviral is justified

End-of-life mental confusion

p.136
Neuroleptics should not be used

Outlook


Exploratory trials, surrogate endpoints: not a robust basis for marketing authorisation

p.137-138

Selecting reliable guidelines: a 10-year analysis of France's official clinical recommendations

p.139
Poor documentation, adverse effects underestimated

Masthead


Free  Masthead

p.114

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