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In Prescrire's Spotlight

Paradigm(s)  Editorial  For decades, the pharmaceutical industry has encouraged patients, students, healthcare professionals and drug regulatory agencies to adopt a way of thinking about drugs focused on their efficacy, trivialising the issue of adverse effects and sometimes even obscuring the dangers they pose to patients. Full article available for download (free) 1 December 2024

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Ivosidenib (Tibsovo°) in the first-line treatment of acute myeloid leukaemia with an IDH1 mutation  Marketing Authorisations   Ivosidenib has been authorised in the European Union, in combination with azacitidine, for the first-line treatment of adult patients with acute myeloid leukaemia and an IDH1 mutation, for whom high-dose cytotoxic chemotherapy is unsuitable. Due to their concurrent development, the azacitidine + ivosidenib combination has not been compared to the azacitidine + venetoclax combination. Full article available for download by subscribers (4 pages) 1 December 2024

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Levetiracetam in utero: long-term effects more clearly defined  Adverse effects   Levetiracetam is an antiepileptic drug for which no particular safety signal has been reported following exposure as monotherapy during the first trimester of pregnancy. As of mid-2024, what is known about the consequences of in-utero exposure to levetiracetam in terms of neuropsychiatric developmental disorders? Full article available for download by subscribers 1 December 2024

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Long-term methylphenidate use: cardiovascular disorders  Adverse effects   According to a study based on Swedish healthcare registers, in adults and children with attention deficit hyperactivity disorder, the risk of cardiovascular disorders increases with the duration of exposure to methylphenidate. After 3 to 5 years of exposure, the risk was increased by about 30%. The risk of hypertension appears to double beyond 5 years of exposure. Full article available for download by subscribers 1 December 2024

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Mediator° disaster: the damning appeal judgement  Outlook   In late December 2023, the Paris appeal court found the pharmaceutical company Servier guilty of all the criminal offences of which it was accused: "aggravated deception", "aggravated involuntary bodily harm and manslaughter", "fraud" and "improperly obtaining" and subsequently renewing marketing authorisation for benfluorex (Mediator°, since withdrawn). Prescrire has published excerpts from the 1101-page judgement, illustrating the position of the appeal judges on Servier's culpability. Full article (4 pages) available for download (free) 1 December 2024

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ New data after marketing authorisation: European Commission consultation (continued)  Advancing Healthcare Policy   In September 2023, Prescrire responded to a consultation organised by the European Commission prior to revising the "Variations Regulation". Full article available for download (free) 1 December 2024

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ EMA: two surveys about the patient leaflet  Advancing Healthcare Policy   In December 2023 and February 2024, Prescrire responded to two surveys organised by the European Medicines Agency (EMA) for the purposes of revising the template that serves as a basis for the patient leaflet (package leaflet) provided with medicinal products and of improving its content and structure. Full article available for download (free) 1 December 2024

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Enjoy these features, and more, in our upcoming issues COMING SOON•  RSV vaccines from 60 years of age • A gene therapy product in haemophilia A • Neuroleptics and dementia: serious adverse effects • Revision of European pharmaceutical legislation (continued)  > Subscribe now 1 December 2024

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Covid-19: Follow Prescrire's independent, evidence-based analysis of the pandemic  COVID-19  Prescrire's editors are publishing an ongoing series of articles featuring independent analysis of developments related to the covid-19 pandemic. Useful and practical information, to help health professionals gain a clear and balanced view. 1 November 2023

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ New! "Top Texts of 2023", from the editors of Prescrire International  FREE SPECIAL EDITION  Check out this sampling of texts from Prescrire International, a wholly independent monthly drug bulletin, written by and for healthcare professionals. Inside, top articles from sections dedicated to new drugs authorised in Europe and key information on adverse drug effects, plus our annual update of drugs to avoid. > Click here for your free copy 1 August 2023

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Subscribe today for full access to top-quality content from Prescrire International  SUBSCRIBE NOW!  Enjoy access to subscriber-only content available on our website, including every article published in Prescrire International since 1992. Prices for a one-year subscription start at 165 euros (less for students and residents of lower-income countries). 1 January 2022

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Follow Prescrire International on Facebook and Twitter Keep up with the latest from Prescrire's editors, and support our values of independence and quality information, first and foremost in the interest of patients. Click here to > Follow us on Facebook or > Follow us on Twitter 1 January 2022

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Receive the free, monthly "Independent Drug & Healthcare Newsletter" Click here to sign up for the free Newsletter from the editors of the non-profit journal Prescrire International, with highlights of the contents of the latest issue. 1 July 2022

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Drugs to avoid, in the name of better patient care   DRUGS TO AVOID - 2024 UPDATE  Independent French medical journal Prescrire has published its annual update of drugs to avoid. The goal is to make it easier to choose high-quality care, and to prevent disproportionate harm to patients. > Read more

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Read more All the subjects in Prescrire's Spotlight >

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