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Spotlight

Every month, the subjects in Prescrire’s Spotlight.

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Psychotic episode: which oral neuroleptic to choose? A choice tailored to each patient, based on the adverse effect profiles of the options

FEATURED REVIEW Neuroleptic drugs have been widely used since the 1950s to treat psychotic episodes. When an oral neuroleptic appears justified for treating a psychotic episode in an adult, which drug should be chosen?
Full review (7 pages) available for download by subscribers.
1 July 2019

In the July-August issue of Prescrire International: emtricitabine + tenofovir disoproxil (Truvada° and other brands) for prevention of HIV infection in adolescents

FREE DOWNLOAD Based on extrapolation of the data obtained in adults, the emtricitabine + tenofovir disoproxil combination (Truvada° or other brands) appears worth offering to adolescents whose sex practices place them at particularly high risk of contracting HIV infection.
Full text available for free download.
1 July 2019

Fentanyl (Actiq° and other brands) and other opioids: risk of increased pain

Paradoxically, fentanyl, like other opioids, can exacerbate the pain it is intended to relieve.
1 July 2019

Prescrire's packaging review for 2018: ways to reduce dangers

A drug's packaging (box, bottle, delivery device, leaflet, etc.) is especially important in preventing patient errors in taking the drug. Hence the usefulness of Prescrire's methodical analysis.
1 July 2019

A clear example of marketing's influence on prescribers

Lung specialists have been influenced by marketing to prescribe new drugs that do not bring any benefits for patients with COPD.
1 July 2019

Methylphenidate (Ritalin° and other brands) during pregnancy: teratogenic and fetotoxic, with concerns about long-term effects

FEATURED REVIEW Methylphenidate is an amphetamine-like psychostimulant used in attention deficit hyperactivity disorder (ADHD). Recent studies have revealed important data about the consequences of in utero exposure to methylphenidate for the unborn child, in the short and long term.
Full review (3 pages) available for download by subscribers.
1 June 2019

In the June issue of Prescrire International - Treatment of scabies: 5% permethrin cream or oral ivermectin?

FREE DOWNLOAD In patients with scabies, topical application of 5% permethrin cream and oral ivermectin have a similar harm-benefit balance. How do these two treatment options stack up?
Full text available for free download.
1 June 2019

Independence and transparency: the words Prescrire lives by

The independent French medical journal Prescrire is 100% financed by its subscribers, guaranteeing freedom from the influence of the special interests – be they industrial or institutional – that are omnipresent in the healthcare arena.
1 June 2019

Atrial fibrillation: apixaban (Eliquis°) as an alternative to warfarin (Coumadin° and other brands) in some situations

When atrial fibrillation warrants the use of an anticoagulant, the anti-vitamin K warfarin (Coumadin° and other brands) is still the best long-term evaluated oral anticoagulant. The anti-Xa apixaban (Eliquis°) is an alternative in some situations.
1 June 2019

Ginkgo biloba: to be avoided due to severe adverse effects

In practice, it is better to avoid this plant, which has no proven efficacy and exposes patients to serious adverse effects, including convulsions.
1 June 2019

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