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Spotlight

Every month, the subjects in Prescrire’s Spotlight.

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Comparative trials: an ethical issue

Mounting evidence that hydroxychloroquine (Plaquenil°) lacks the efficacy expected in covid-19 has shown the medical and ethical risks of using drugs on the basis of inadequate evidence.
1 March 2021

Prescrire’s response to the European Commission consultation on a "European Health Emergency Preparedness and Response Authority"

23 February 2021

Covid-19 and ivermectin: many trials, few results, no proven efficacy

 NEWS UPDATE  The antiparasitic drug ivermectin has been shown to have in vitro activity against Sars-CoV-2. What are the main results available in early February 2021 from comparative clinical trials of ivermectin in the treatment and prevention of covid-19?
13 February 2021

The ChAdOx1 nCoV-19 covid-19 vaccine from AstraZeneca: great uncertainty over its efficacy

 NEWS UPDATE  Unlike the first two covid-19 vaccines authorised in Europe, which are messenger RNA vaccines, the covid19 vaccine ChAdOx1 nCoV-19, developed by the University of Oxford and the pharmaceutical company AstraZeneca, is a "viral vector" vaccine. What are the main data available in late January 2021 from the clinical trials of this new vaccine?
29 January 2021

Prescrire publishes its annual update of drugs to avoid, in the name of better patient care

  DRUGS TO AVOID - 2021 UPDATE  For the ninth consecutive year, independent French medical journal Prescrire has published its annual update of drugs to avoid. The goal is to make it easier to choose high-quality care, and to prevent disproportionate harm to patients
1 February 2021

Ebola vaccine rVSV-Zebov (Ervebo°) in an outbreak of Ebola virus disease. Major reduction in incidence among those at risk for this often-fatal infection

FEATURED REVIEW Ebola virus disease is a contagious and often fatal infection for which there was no vaccine or cure. According to two clinical trials, the live attenuated vaccine, Ebola vaccine rVSV-Zebov, confers high levels of protection to people who come into contact with infected patients.
Full review (5 pages) available for download by subscribers.
1 February 2021

In the February issue of Prescrire International: Liposomal forms of drugs

FREE DOWNLOAD Healthcare professionals must take great care at every stage of the medication-use process when dealing with drugs that are available in liposomal and non-liposomal forms.
Full text available for free download.
1 February 2021

Like any other drug?

EDITORIALAs with any other drug, the data available for the analysis of a vaccine's adverse effects are often less robust than those available for analysis of its efficacy. When all factors are taken into account, a vaccine sometimes clearly represents a therapeutic advance
1 February 2021

Pregabalin (Lyrica° and other brands): abuse and dependence on the increase

Given the increase in cases of pregabalin abuse and dependence, the need for prescription should be kept under regular review, as well as any potentially dangerous combinations with other drugs.
1 February 2021

Smoking cessation induces toxic dose levels of certain drugs

Toxic dose levels (alias overdose) of certain drugs have been observed a few weeks after the patient stopped smoking. Some had serious consequences, especially those involving a drug with a narrow therapeutic index.
1 February 2021

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