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Spotlight

Every month, the subjects in Prescrire’s Spotlight.

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In the February issue of Prescrire International: Midostaurin (Rydapt°) for some types of acute myeloid leukaemia

FREE DOWNLOAD In this month's sample review, Prescrire's editors give this multi-tyrosine kinase inhibitor a rating of "Offers an advantage", but warn that the drug's adverse effects are underestimated.
Full text available for free download.
1 February 2019

MRI during pregnancy: the pros and cons should be carefully assessed

Before deciding to give a pregnant woman an MRI scan, with or without contrast agents, it is important to consider how the MRI results would change the clinical course.
1 February 2019

Proton pump inhibitors: increased mortality

FEATURED REVIEW Proton pump inhibitors (PPIs) such as omeprazole are used in oesophagitis, gastroesophageal reflux disease and peptic ulcer disease. PPIs have few severe adverse effects in the short term. But this is not the case in the long term.
Full review (3 pages) available for download by subscribers.
1 January 2019

In the January issue of Prescrire International: Pembrolizumab (Keytruda°) in urothelial carcinoma

FREE DOWNLOAD In this month's sample review: Prescrire's editors rate pembrolizumab (Keytruda°) "Possibly helpful" in certain patients with locally advanced or metastatic urothelial carcinoma.
Full text available for free download.
1 January 2019

Nonsteroidal anti-inflammatory drugs in pharyngitis: risk of peritonsillar abscess

To relieve fever or sore throat, it is better not to use nonsteroidal anti-inflammatory drugs (NSAIDs), but to use paracetamol instead.
1 January 2019

Drug companies enjoy impunity from EU authorities

Under European regulations, the European Commission can only impose a financial penalty on drug companies if their infringement has "substantial consequences for public health" and if they do not co-operate during the proceedings brought against them.
1 January 2019

COPD exacerbation: no systematic use of antibiotics

For episodes of moderate aggravation in patients with chronic obstructive pulmonary disease (COPD), it is preferable to prescribe antibiotics as a first-line treatment only when the suspicion of bacterial infection is reinforced by an increase in sputum purulence.
1 January 2019

Healthcare-related errors: describe them in detail to understand them better

FEATURED REVIEW The realisation that a healthcare-related adverse effect was preventable is not enough to prevent similar errors. Error prevention also requires an understanding of the root causes, through in-depth analysis, preferably with everyone involved, including the patient.
Full review (5 pages) available for download by subscribers.
1 December 2018

In the December issue of Prescrire International: Stable angina and antithrombotic drugs

FREE DOWNLOAD Addition of rivaroxaban (Xarelto°) to aspirin increases the risk of serious bleeding, but it has not been shown that the harm-benefit balance of this addition is favourable. Aspirin alone remains the first-choice antithrombotic drug in the majority of patients with coronary disease.
Full text available for free download.
1 December 2018

Opioid overdose: an antidote to be administered promptly

Naloxone nasal spray (Nalscue°) is easy to use, and can save the lives of people who have overdosed on opioids.
1 December 2018

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