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Spotlight

Every month, the subjects in Prescrire’s Spotlight.

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Cabotegravir (Vocabria°) and rilpivirine (Rekambys°) intramuscular injections in HIV infection

FEATURED REVIEW The standard treatment for patients with HIV infection is a combination of at least three antiretro­virals. An oral two-­drug regimen is sometimes considered. How do Prescrire's editors rate this combination, administered by intramuscular injection?
Full review (2 pages) available for download by subscribers.
1 April 2022

In the April issue of Prescrire International: Dupilumab (Dupixent°) in severe atopic eczema from 6 years of age

FREE DOWNLOAD Dupilumab is an immunosuppressant monoclonal antibody which was already authorised in the European Union for use in adults and adolescents with troublesome atopic eczema. How do Prescrire's editors rate this drug in younger children?
Full text available for free download.
1 April 2022

Balancing act

 Editorial  Making healthcare decisions is a balancing act, sometimes a tricky one. When the data are insubstantial or non-existent, the greater the uncertainty and the trickier the balancing act.
1 April 2022

The Innovative Medicines Initiative: a European public-private partnership that mostly benefits Big Pharma

IN FOCUSEurope's "Joint Technology Initiative on Innovative Medicines" (IMI) was created in 2007. The official objective was to improve the drug development process, so that the pharmaceutical sector could produce safer, more effective new drugs in the long term. How has the partnership measured up?
Full review (4 pages) available for download by subscribers.
1 April 2022

Drugs in 2021: a brief review

Just 17 of the 108 new marketing authorisations analysed and rated in our French edition in 2021 represented a major or notable therapeutic advance for patients. How does this finding for 2021 compare with prior years?
1 April 2022

Fentanyl: overdose and dependence with fast-acting forms

Fast-acting forms of fentanyl, a strong opioid analgesic, must be used with caution, patients must be thoroughly informed, and excessive doses must be avoided.
1 April 2022

Isotretinoin: too many pregnancies still at risk

Despite a series of measures, unborn children are still being exposed to isotretinoin during pregnancy, with a risk of serious malformations and/or neuropsychiatric disorders.
1 April 2022

Down with the "p value"! A move to democratise health information

1 April 2022

• Down with the decline in vigilance! Mind your p's and q's

In today's ever more skewed world, it's more important than ever to use every tool at one's disposal to determine if a result is significant. Or just plain old fishy.
1 April 2022

Watch the video of the webinar "Prescrire, A Critical Eye on New Drugs"

 VIDEO  How many new drugs offer an advantage and how many bring nothing new? Prescrire has been answering this key question since 1981. In a March 2022 webinar organised by Consilium Scientific, Pierre Chirac of Prescrire explained the reason for Prescrire's existence, the people behind it, its operations, its main achievements, and its limitations.
21 March 2022

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