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Spotlight

Every month, the subjects in Prescrire’s Spotlight.

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COPD exacerbation: no systematic use of antibiotics

For episodes of moderate aggravation in patients with chronic obstructive pulmonary disease (COPD), it is preferable to prescribe antibiotics as a first-line treatment only when the suspicion of bacterial infection is reinforced by an increase in sputum purulence.
1 January 2019

Healthcare-related errors: describe them in detail to understand them better

FEATURED REVIEW The realisation that a healthcare-related adverse effect was preventable is not enough to prevent similar errors. Error prevention also requires an understanding of the root causes, through in-depth analysis, preferably with everyone involved, including the patient.
Full review (5 pages) available for download by subscribers.
1 December 2018

In the December issue of Prescrire International: Stable angina and antithrombotic drugs

FREE DOWNLOAD Addition of rivaroxaban (Xarelto°) to aspirin increases the risk of serious bleeding, but it has not been shown that the harm-benefit balance of this addition is favourable. Aspirin alone remains the first-choice antithrombotic drug in the majority of patients with coronary disease.
Full text available for free download.
1 December 2018

Opioid overdose: an antidote to be administered promptly

Naloxone nasal spray (Nalscue°) is easy to use, and can save the lives of people who have overdosed on opioids.
1 December 2018

Drugs for hepatitis C: it's time to slash prices!

The high prices of hepatitis C drugs are an obstacle to treatment for most of the people around the world who are infected by the virus.
1 December 2018

Avoid pregnancy during treatment with valproic acid or its derivatives

New measures have been taken in the European Union to prevent the exposure of fetuses to valproic acid and its derivatives.
1 December 2018

Drug-induced gynaecomastia

FEATURED REVIEW  Drug-related proliferation of male breast tissue generally subsides after discontinuation of the substance that caused it. This must be weighed against the potential disadvantages of stopping treatment or substituting another drug.
Full review (5 pages) available for download by subscribers.
1 November 2018

In the November issue of Prescrire International: Ending pharmaceutical sales representatives' access to hospitals and students

FREE DOWNLOAD In-person promotion of drugs to healthcare professionals by pharmaceutical sales representatives, known as pharmaceutical detailing, has been shown to influence doctors' prescribing behaviour. A US study looked at ways to limit this influence.
Full text available for free download.
1 November 2018

Alcohol dependence: the risks of high-dose baclofen

With high-dose baclofen, there is an increased risk of epilepsy, infection, myocardial infarction or suicidal thoughts.
1 November 2018

Denosumab (Prolia°) and osteoporosis: an increasingly unfavourable harm-benefit balance

Reports of sometimes serious adverse effects tilt the harm-benefit balance of denosumab in the treatment of osteoporosis.
1 November 2018

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