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Spotlight

Every month, the subjects in Prescrire’s Spotlight.

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Clinical trials of drugs: the various types of placebo used

In certain situations, the best way of telling the extent to which a treatment's apparent effects are due to the natural history of the disease or the treatment itself is to compare it with a placebo.
1 November 2020

  The 2020 "Prescrire Prize" is awarded in Paris to
  3 noteworthy books about health and healthcare

The recipients of the 2020 "Prescrire Prize" book awards were announced on 1 October 2020. The prize is awarded to works of particular interest to the general public and/or healthcare professionals.
1 October 2020

Apixaban, edoxaban, rivaroxaban: situations with a high risk of bleeding or thrombosis

FEATURED REVIEW When using xabans, it is essential to take into account the situations that increase the risk of bleeding or thrombosis, and to monitor the patient for any change in these risks, such as new comorbidities, new drugs, or discontinued drugs.
Full review (4 pages) available for download by subscribers.
1 October 2020

In the October issue of Prescrire International: A public awareness campaign which mainly benefits companies

FREE DOWNLOAD The pharmaceutical company Abbvie, which markets adalimumab (Humira°), has jointly funded a public awareness campaign produced by the patient organisation France Psoriasis. Objective: marketing.
Full text available for free download.
1 October 2020

Hydroxychloroquine: the situation is critical

EDITORIALAccording to the methodological principles of clinical evaluation, comparative trials provide the most reliable evidence when evaluating treatments. The lowest-level evidence comes from expert opinions, case series, other observational studies and empiricism. This is still true in 2020 – and also in covid-19.
1 October 2020

Gentian violet used when breastfeeding: irritant and carcinogenic

Gentian violet has no place in the treatment of nipple thrush while breastfeeding, nor of oral thrush in the newborn baby.
1 October 2020

Pinworm infection: easy to detect and easy to treat

Anal itching at night is highly suggestive of pinworm infection, an intestinal parasitic infection that is very common in children. Several drugs, none of which have serious adverse effects, eradicate the parasites, after two doses, given two weeks apart.
1 October 2020

Proton pump inhibitors: increased risk of severe covid-19

 NEWS UPDATE  Proton pump inhibitors (PPIs) are known to increase the risk of various infections, including pneumonia and pseudomembranous colitis. What about covid-19 infection? A recent study yields some useful information.
15 September 2020

Covid-19 patients who are not hospitalised: anticoagulation is rarely justified

 NEWS UPDATE  The risk of thromboembolism in patients with a mild to moderate form of covid-19 is unclear and probably varies greatly between patients. Is anticoagulation justified to prevent deep vein thrombosis in patients with covid-19 who are not hospitalised?
24 September 2020

Cannabidiol (Epidyolex°) in certain severe forms of childhood epilepsy: an option to consider, but liver function must be monitored

FEATURED REVIEW Cannabidiol (Epidyolex°) has been granted marketing authorisation in the European Union for patients aged 2 years and older with Lennox-Gastaut syndrome or Dravet syndrome, in combination with antiepileptic treatment including at least clobazam. How do Prescrire's editors rate this treatment in this situation?
Full text (3 pages) available for download by subscribers.
1 September 2020

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