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In Prescrire's Spotlight

Viral vector covid-19 vaccine ChAdOx1-S (Vaxzevria°) and covid-19. Efficacy in the short term, but a risk of rare, sometimes fatal, thrombosis FEATURED REVIEW Following two mRNA vaccines, a viral vector vaccine, the covid-19 vaccine ChAdOx1-S (Vaxzevria°, AstraZeneca), has been authorised in the European Union. Like the two mRNA vaccines, this vaccine triggers an immune response against the S glycoprotein of Sars-CoV-2. Full review (3 pages) available for download by subscribers. 1 September 2021

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ In the September issue of Prescrire International - Psoriasis and ixekizumab: turn first to standard systemic treatments FREE DOWNLOAD There is no strong evidence that ixekizumab has greater efficacy than methotrexate in patients with psoriasis. In addition, its adverse effects are less well established than those of standard treatments, particularly in the long term. Full text available for free download. 1 September 2021

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Preventable deaths  Editorial  A number of high-profile court cases have brought attention to thousands of victims made sick by their medication. It is within our grasp to prevent many patients from becoming victims, without waiting for scandals to erupt, by being cautious and attentive: attentive, first and foremost, to doing no harm. 1 September 2021

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Drug-induced sudden cardiac death and long QT syndrome Many drugs directly increase the QT interval on the electrocardiogram, a disorder of electrical conduction associated with a risk of sometimes fatal cardiac disorders. 1 September 2021

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Stopping antidepressant therapy: plan tapered withdrawal When stopping antidepressant therapy, reducing the dose stepwise over a period of more than 4 weeks helps to limit withdrawal symptoms. 1 September 2021

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Prescrire's annual review: drug packaging in 2020 Drug packaging is a key determinant of drug quality and is sometimes the deciding factor when choosing between treatments, in the interests of safety. It is still too often neglected by drug companies and regulators. 1 September 2021

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Trabectedin (Yondelis°): more dangerous than beneficial in ovarian cancer, yet the EMA maintains its position  Outlook  The European Medicines Agency chose not to take into account data showing the significant toxicity of trabectedin and the lack of a tangible clinical benefit for patients. It is up to healthcare professionals to avoid exposing patients to this drug, which is more dangerous than beneficial. 1 September 2021

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Covid-19 : Follow Prescrire's independent, evidence-based analysis of the pandemic  COVID-19  Prescrire's editors are publishing an ongoing series of articles featuring independent analysis of developments related to the covid-19 pandemic. Useful and practical information, to help healthcare professionals gain a clear and balanced view. 1 September 2021

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Enjoy these features, and more, in our upcoming issues COMING SOONBulevirtide and chronic hepatitis D • Vaccine efficacy against the Delta variant • Difficulties encountered on discontinuing topical corticosteroids • Ranitidine: marketing authorisation suspended due to impurities • Supplementary protection certificates... > Subscribe now 1 September 2021

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ "Top Texts of 2021", from the editors of Prescrire International  NEW! FREE SPECIAL EDITION  Check out this brand new sampling of texts from Prescrire International, a wholly independent monthly drug bulletin, written by and for healthcare professionals. Inside, top articles from our "New Products", "Adverse Effects" and "Reviews" sections, plus our annual update of drugs to avoid. > Click here for your free copy 1 August 2021

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Follow Prescrire International on Facebook and Twitter Keep up with the latest from Prescrire's editors, and support our values of independence and quality information, first and foremost in the interest of patients. Click here to > Follow us on Facebook or > Follow us on Twitter 1 September 2021

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Subscribe today for full access to top-quality content from Prescrire International Subscribe now Enjoy access to subscriber-only content available on our website, including every article published in Prescrire International since 1992. Prices for a one-year subscription start at 150 euros (less for students and residents of lower-income countries). 1 September 2021

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Receive the free, monthly "Independent Drug & Healthcare Newsletter" Click here to sign up for the free Newsletter from the editors of the non-profit journal Prescrire International, with highlights of the contents of the latest issue. 1 September 2021

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Drugs to avoid, in the name of better patient care   DRUGS TO AVOID - 2021 UPDATE  Independent French medical journal Prescrire has published its annual update of drugs to avoid. The goal is to make it easier to choose high-quality care, and to prevent disproportionate harm to patients. > Read more

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Read more All the subjects in Prescrire's Spotlight >

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