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In Prescrire's Spotlight

Nirmatrelvir + ritonavir (Paxlovid°) in covid-19, for certain patients at risk of developing severe disease FEATURED REVIEW The combination of nirmatrelvir + ritonavir (Paxlovid°) is an oral antiviral treatment for adults with covid-19 who have had symptoms for 5 days at most and do not require oxygen therapy, but who have at least one risk factor for developing severe covid-19. How do Prescrire's editors rate this combination in this situation? Full review (4 pages) available for download by subscribers. 1 June 2022

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ In the June issue of Prescrire International. Hydroxycarbamide: interstitial lung disease FREE DOWNLOAD Hydroxycarbamide, alias hydroxyurea, is a cytotoxic drug administered orally in some myeloproliferative syndromes, and to some patients with sickle cell disease to prevent acutely painful vaso-occlusive crises, acute chest syndrome and hospitalisation. Full text available for free download. 1 June 2022

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Not that common  Editorial  Independence. Transparency. Two words that are overused, especially in the field of health care. Prescrire takes transparency as far as publishing its financial statement every year. Which is not that common. 1 June 2022

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Prescrire's finances: 2021 annual report Association Mieux Prescrire (AMP), the legal entity responsible for Prescrire's publications, is a non-profit organisation that makes its accounts public every year. The annual report for 2021 appears in the June issue of Prescrire International, and online here. 1 June 2022

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Messenger RNA covid-19 vaccines tozinameran (Comirnaty°) and elasomeran (Spikevax°) during pregnancy in focusWhat main points should pregnant women be aware of in order to make informed decisions about covid-19 vaccination? 1 June 2022

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Peanut allergy: peanut-avoidant diet and access to adrenaline injector pens For patients with peanut allergy, complete elimination of peanuts from the diet and access to adrenaline pens is a better option than oral desensitisation. 1 June 2022

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Strategic choices  Editors' Opinion  Choosing certain endpoints in clinical trials can mask outcomes that really matter to patients. It is certainly not a strategy that ensures high-quality treatments that improve patient care. 1 June 2022

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Depression: possible increase in the risk of suicide with esketamine (Spravato°) Clinical trials and pharmacovigilance data show a possible increase in the risk of suicide with esketamine (Spravato°), a drug authorised for use in "treatment-resistant" depression and "psychiatric emergencies". 1 June 2022

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Covid-19 : Follow Prescrire's independent, evidence-based analysis of the pandemic  COVID-19  Prescrire's editors are publishing an ongoing series of articles featuring independent analysis of developments related to the covid-19 pandemic. Useful and practical information, to help health professionals gain a clear and balanced view. 1 June 2022

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Enjoy these features, and more, in our upcoming issues COMING SOON • Rivaroxaban in children • Tucatinib in HER2-positive breast cancer • Drug-induced, abnormal body odours • Prescrire is taking action at the European level. > Subscribe now 1 June 2022

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Subscribe today for full access to top-quality content from Prescrire International  SUBSCRIBE NOW!  Enjoy access to subscriber-only content available on our website, including every article published in Prescrire International since 1992. Prices for a one-year subscription start at 150 euros (less for students and residents of lower-income countries). 1 January 2022

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Follow Prescrire International on Facebook and Twitter Keep up with the latest from Prescrire's editors, and support our values of independence and quality information, first and foremost in the interest of patients. Click here to > Follow us on Facebook or > Follow us on Twitter 1 January 2022

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ "Top Texts of 2021", from the editors of Prescrire International  FREE SPECIAL EDITION  Check out this sampling of texts from Prescrire International, a wholly independent monthly drug bulletin, written by and for healthcare professionals. Inside, top articles from sections dedicated to new drugs authorised in Europe and updates on adverse drug effects, plus our annual update of drugs to avoid. > Click here for your free copy 1 January 2022

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Receive the free, monthly "Independent Drug & Healthcare Newsletter" Click here to sign up for the free Newsletter from the editors of the non-profit journal Prescrire International, with highlights of the contents of the latest issue. 1 January 2022

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Drugs to avoid, in the name of better patient care   DRUGS TO AVOID - 2022 UPDATE  Independent French medical journal Prescrire has published its annual update of drugs to avoid. The goal is to make it easier to choose high-quality care, and to prevent disproportionate harm to patients. > Read more

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Read more All the subjects in Prescrire's Spotlight >

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