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Spotlight

Every month, the subjects in Prescrire’s Spotlight.

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Methylphenidate (Ritalin° and other brands) during pregnancy: teratogenic and fetotoxic, with concerns about long-term effects

FEATURED REVIEW Methylphenidate is an amphetamine-like psychostimulant used in attention deficit hyperactivity disorder (ADHD). Recent studies have revealed important data about the consequences of in utero exposure to methylphenidate for the unborn child, in the short and long term.
Full review (3 pages) available for download by subscribers.
1 June 2019

In the June issue of Prescrire International - Treatment of scabies: 5% permethrin cream or oral ivermectin?

FREE DOWNLOAD In patients with scabies, topical application of 5% permethrin cream and oral ivermectin have a similar harm-benefit balance. How do these two treatment options stack up?
Full text available for free download.
1 June 2019

Independence and transparency: the words Prescrire lives by

The independent French medical journal Prescrire is 100% financed by its subscribers, guaranteeing freedom from the influence of the special interests – be they industrial or institutional – that are omnipresent in the healthcare arena.
1 June 2019

Atrial fibrillation: apixaban (Eliquis°) as an alternative to warfarin (Coumadin° and other brands) in some situations

When atrial fibrillation warrants the use of an anticoagulant, the anti-vitamin K warfarin (Coumadin° and other brands) is still the best long-term evaluated oral anticoagulant. The anti-Xa apixaban (Eliquis°) is an alternative in some situations.
1 June 2019

Ginkgo biloba: to be avoided due to severe adverse effects

In practice, it is better to avoid this plant, which has no proven efficacy and exposes patients to serious adverse effects, including convulsions.
1 June 2019

Useful tips for informing patients about risks

The vast majority of patients would like more explanations in order to better understand their state of health and to participate in therapeutic choices that affect them. How can healthcare professionals deliver this?
1 June 2019

Drug-induced retinal disorders

FEATURED REVIEW Retinal damage can cause different types of visual disturbances, of varying severity. Many drugs can provoke retinal disorders. What are the underlying mechanisms? Which drugs are responsible?
Full review (4 pages) available for download by subscribers.
1 May 2019

In the May issue of Prescrire International: Dupilumab (Dupixent°) in adults with atopic dermatitis

FREE DOWNLOAD Dupilumab (Dupixent°), a monoclonal antibody, is an option for very troublesome eczema after failure of ciclosporin. Full text available for free download.
1 May 2019

Vaccine hesitancy: understand it better, to provide better support

Rather than considering people reluctant to vaccinate as irresponsible, it is better to try to restore confidence by improving public knowledge, identifying the barriers and seeking ways to overcome them.
1 May 2019

Drugs for Alzheimer's disease: reduction in the number of prescriptions is too slow

A study conducted by the independent French medical journal Prescrire shows a reduction of only around 26% in the number of patients in France exposed to at least one Alzheimer's disease drug between 2012 and 2017. In approximately 3 out of 4 newly exposed patients, treatment lasted for more than 6 months, despite the proven harms.
1 May 2019

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