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Spotlight

Every month, the subjects in Prescrire’s Spotlight.

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Drug prices, therapeutic value and access to medicines: civil society adds its voice to the debate in France, to defend the public interest

20 June 2018

Drugs for Alzheimer's disease: finally delisted in France!

The drugs available in mid-2018 for Alzheimer's disease have only minimal and transient efficacy. They have disproportionate, serious and sometimes fatal adverse effects. It is better to avoid them and to focus instead on reorganising the patient's daily life, keeping him or her active, and providing support and help for caregivers and family members.
15 June 2018

Human papillomavirus 9-valent vaccine (Gardasil 9°) and cervical cancer. A few cases of dysplasia prevented, but an increase in painful reactions

FEATURED REVIEW A human papillomavirus (HPV) vaccine containing 9 HPV genotypes (Gardasil 9°) has been authorised in the European Union. The 9-valent vaccine provokes more, sometimes severe, injection site reactions, which could intensify existing misgivings about HPV vaccination.
Full review (2 pages) available for download by subscribers.
1 June 2018

In the June issue of Prescrire International: anti-TNF alpha is linked to lymphoma; tropicamide eye drops present a risk of misuse

FREE DOWNLOADDownload this free page from the Adverse Effects section of the June issue, to get a sampling of the quality and diversity of the information published in every issue of Prescrire International.
Full text available for free download.
1 June 2018

Antibiotics: repeated treatments before the age of two could be a factor in obesity

Antibiotics disrupt the intestinal flora (intestinal microbiota) and could be a factor in weight gain. Prescription of antibiotics for children should not be automatic but should be evaluated on a case-by-case basis.
1 June 2018

Independence, in the service of patients' best interests

Prescrire is 100% financed by its subscribers, which guarantees its freedom from the influence of any special interests – be they industrial or institutional. This is the precondition for reliable, unbiased information and continuing education for healthcare professionals.
1 June 2018

Wholly self-financed through subscriptions, Prescrire makes its accounts public every year

1 June 2018

Metopimazine: cardiac disorders

FEATURED REVIEW Metopimazine has received much less attention than domperidone in regard to its cardiovascular adverse effects, but the limited data available suggest that it probably exposes patients to a risk similar to that of domperidone.
Full review (4 pages) available for download by subscribers.
1 May 2018

In the May issue of Prescrire International: Psychiatric disorders following in utero exposure to diethylstilbestrol (DES)

FREE DOWNLOAD In utero exposure to DES results in a variety of harmful effects, including long-term harms. Psychiatric disorders reported for "DES daughters" and "DES sons" include depression, bipolar disorder, behavioural disorders and schizophrenia.
Full text available for free download.
1 May 2018

Exploratory trials, surrogate endpoints: not a robust basis for marketing authorisation

To serve the best interests of patients, it is more necessary than ever to base marketing authorisation decisions on robust data.
1 May 2018

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