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Spotlight

Every month, the subjects in Prescrire’s Spotlight.

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Ebola vaccine rVSV-Zebov (Ervebo°) in an outbreak of Ebola virus disease. Major reduction in incidence among those at risk for this often-fatal infection

FEATURED REVIEW Ebola virus disease is a contagious and often fatal infection for which there was no vaccine or cure. According to two clinical trials, the live attenuated vaccine, Ebola vaccine rVSV-Zebov, confers high levels of protection to people who come into contact with infected patients.
Full review (5 pages) available for download by subscribers.
1 February 2021

In the February issue of Prescrire International: Liposomal forms of drugs

FREE DOWNLOAD Healthcare professionals must take great care at every stage of the medication-use process when dealing with drugs that are available in liposomal and non-liposomal forms.
Full text available for free download.
1 February 2021

Like any other drug?

EDITORIALAs with any other drug, the data available for the analysis of a vaccine's adverse effects are often less robust than those available for analysis of its efficacy. When all factors are taken into account, a vaccine sometimes clearly represents a therapeutic advance
1 February 2021

Pregabalin (Lyrica° and other brands): abuse and dependence on the increase

Given the increase in cases of pregabalin abuse and dependence, the need for prescription should be kept under regular review, as well as any potentially dangerous combinations with other drugs.
1 February 2021

Smoking cessation induces toxic dose levels of certain drugs

Toxic dose levels (alias overdose) of certain drugs have been observed a few weeks after the patient stopped smoking. Some had serious consequences, especially those involving a drug with a narrow therapeutic index.
1 February 2021

The covid-19 messenger RNA vaccine from Moderna: as with the tozinameran vaccine (Comirnaty°, Pfizer/BioNTech), limited data and unanswered questions

 NEWS UPDATE  As of early January 2021, the covid-19 vaccine mRNA-1273 Sars-CoV-2, from the pharmaceutical company Moderna, is expected to be approved for use in the European Union. In France, this vaccine is to be offered first to elderly residents of nursing homes and similar facilities, and to certain health professionals. What are the main evaluation data obtained with this vaccine in these populations?
06 January 2021

SSRI antidepressants and pregnancy: long-term neuropsychiatric disorders in exposed children?

FEATURED REVIEW Data available in 2017 suggested that in utero exposure to SSRI antidepressants increases the risk of autism. Do we have a clearer idea in 2020 of the long-term neuropsychiatric harms to the unborn child posed by the use of SSRI antidepressants during pregnancy?
Full review (3 pages) available for download by subscribers.
1 January 2021

In the January issue of Prescrire International: Dasatinib (Sprycel° and other brands) in children with acute lymphoblastic leukaemia

FREE DOWNLOAD Dasatinib has been granted marketing authorisation in the European Union as first-line therapy added to chemotherapy for children with Philadelphia chromosome-positive acute lymphoblastic leukaemia.
Full text available for free download.
1 January 2021

A two-step approach

EDITORIAL In the midst of the covid-19 crisis, Prescrire is fulfilling its mission via a two-step approach. Rapidly sharing key information, distinguishing fact from hypothesis and opinion. Then helping healthcare professionals to make rational choices, based on documented evidence rather than wishful thinking. Taking care not to confuse urgent action with undue haste.
1 January 2021

Treatment-resistant depression: avoid esketamine (Spravato°)

Esketamine nasal spray (Spravato°) has been authorised for use in so-called "treatment-resistant" depression. Its efficacy is uncertain, and its harm-benefit balance is unfavourable due to serious adverse effects including neuropsychiatric and cardiac disorders.
1 January 2021

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