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In Prescrire's Spotlight

Deep venous thrombosis and pulmonary embolism:
prevention of recurrences

FEATURED REVIEW After the initial phase of treatment for deep venous thrombosis or pulmonary embolism, the goal is to prevent recurrences, which can be fatal. In practice, it is best to choose between low-molecular weight heparin (LMWH) and warfarin, on a case-by-case basis.
Full review (5 pages) available for download by subscribers.

1 May 2013

In the May issue of Prescrire International: Panitumumab (Vectibix°) as adjunctive therapy for metastatic colorectal cancer

FREE DOWNLOAD This text from the New Products section of the May issue of Prescrire International concludes that panitumumab has no place in either first- or second-line treatment of metastatic colorectal cancer.

Full text available for free download.

1 May 2013

Lessons learnt and to be learnt: PRAC and CHMP say no to dangerous drug

In a published response to Gary Taube's essay "The science of obesity: what do we really know about what makes us fat?" (BMJ online, 16 April 2013), Prescrire welcomes the European Medicines Agency's refusal to grant marketing authorisation to the fixed-dose combination of topiramate and phentermine.

26 April 2013

Prescrire looks back at drugs packaging in 2012: too many dangerous flaws

The analyses carried out over the past year by Prescrire's editors reveal that in too many cases, drug packaging is dangerous for children. Too many patient leaflets contain incomplete information on adverse effects, resulting in the most vulnerable patients being the least protected.

1 May 2013

Oral methotrexate: risk of a fatal overdose

The packaging of oral methotrexate-based drugs should be improved so as to avoid fatal dosage errors.

1 May 2013

Idiopathic pulmonary fibrosis: avoid pirfenidone (Esbriet°)

The lack of an effective treatment for idiopathic pulmonary fibrosis, a rare disease, does not justify the use of pirfenidone: this drug's harm-benefit balance is unfavourable.

1 May 2013

Health research: fraud is too widespread!

It is high time to put an end to the blind faith placed in researchers’ findings, and to make it possible for their results to be verified.

1 May 2013

Mephenesin: abuse and dependence

Mephenesin is a muscle relaxant with psychotropic effects, leading to abuse and dependence. It is better to avoid mephenesin, especially in patients with a history of abuse and dependence.

1 May 2013

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1 August 2012

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