english.prescrire.org > Spotlight > 100 most recent > In the January issue of Prescrire International: adverse effects of pseudoephedrine and sofosbuvir

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In the January issue of Prescrire International: adverse effects of pseudoephedrine and sofosbuvir

FREE DOWNLOAD In the "Adverse Effects" section of this month's issue, ischaemic colitis with the decongestant pseudoephedrine, and a risk of pulmonary arterial hypertension with the hepatitis C drug sofosbuvir.
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Pseudoephedrine: ischaemic colitis

  • Sympathomimetic vasoconstrictors can provoke neurological and cardiovascular adverse effects, including hypertensive crisis, stroke and arrhythmia. A few cases of localised colonic ischaemia have been reported
     
  • There is no justification for using drugs capable of provoking ischaemic events, with potentially serious or even fatal consequences, simply to alleviate a few transient and complication-free symptoms of the common cold. 

Sofosbuvir: pulmonary arterial hypertension?

  • The serious adverse drug reactions reported in France with sofosbuvir for the treatment of hepatitis C include 7 cases of pulmonary arterial hypertension (PAH).
     
  • Very little research was conducted on the adverse effects of sofosbuvir before its market introduction. Healthcare professionals must pay attention to events that occur during treatment and report them

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 ©Prescrire 1 January 2017

Prescrire Int 2017; 26 (178): 20. (Pdf, free)

 

 
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