english.prescrire.org > Prescrire International > N°159 - April 2015

n°159

April 2015

Issue Contents
Editorial

Free  Masthead

p.86

Free  Preconceptions based on drug origin

p.88
Plant-based medicines can be harmful

New Products


Vemurafenib (Zelboraf°) with longer follow-up

p.89-90
Metastatic melanoma: a few extra months of life, but many adverse effects

Dabrafenib (Tafinlar°)

p.90
Metastatic melanoma: a me-too of vemurafenib

Dimethyl fumarate (Tecfidera°)

p.91
Multiple sclerosis: too many long-term unknowns

INN common stem: -rafenib

p.91

Free  Green tea leaf extract (Veregen°)

p.92
An aggressive topical treatment for anogenital warts

SC trastuzumab (Herceptin°)

p.93
Ready to use, but more serious adverse effects than IV trastuzumab

Diacerein

p.94
A controversial EU re-evaluation upholds marketing authorisation, unfortunately

Kaneuron°

p.95
An oral solution of phenobarbital with dangerous packaging

Ipilimumab (Yervoy°) and inoperable or metastatic melanoma

p.96
More evaluation needed, in both first- and second-line use

Adverse Effects


Topical minoxidil: accidental poisoning in children

p.97
Hypotension and persistent tachycardia

Acute kidney injury due to drug-induced hypersensitivity

p.97
Stop medication as soon as possible

Weekly methotrexate: harmful to exposed embryos

p.98
Miscarriages and major malformations

Ambroxol, bromhexine: anaphylactic reactions

p.98
Unfavourable harm-benefit balance

Growth hormone: brain haemorrhage

p.98
Epidemiological study

Reviews


Mammographic breast cancer screening - Part II

p.99-102
Non-randomised comparisons: results similar to those of randomised trials

Identifying the least biased studies

p.102

Hypoglycaemic therapy in type 2 diabetes - Part I

p.103-106
Metformin is the only glucose-lowering drug known to prevent complications of diabetes

Types of glucose-lowering drugs and their mechanisms of action

p.105

Outlook


Free  New drugs and indications in 2014

p.107-110
Some advances this year, but many drugs are poorly evaluated, too expensive or more dangerous than useful

Free  No-gift policy in medical schools

p.111
Demonstrated impact on prescribing behaviour

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