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In Prescrire's Spotlight

A tale of risk  Editorial  Each drug has its own story. Some are fine tales of discovery: the discovery of a rare or not so rare disease, its serious or not so serious consequences, its natural course and causes, and then an effective treatment. In the best stories, the treatment benefits numerous patients for a very long time, its risks are considered acceptable, and the price society pays for it is fair.  Full article available for download (free) 1 June 2024

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Faricimab (Vabysmo°) in age-related macular degeneration or diabetic macular oedema  Marketing Authorisations   Faricimab is a monoclonal antibody that simultaneously targets 2 proteins involved in angiogenesis: vascular endothelial growth factor (VEGF) and angiopoietin-2. It has been authorised in the European Union for intravitreal use in adults with neovascular (wet) age-related macular degeneration and in adults with loss of visual acuity due to diabetic macular oedema. What advantages does faricimab offer over VEGF inhibitors in these clinical situations? And what are its adverse effects? Full article available for download by subscribers 1 June 2024

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Semaglutide in secondary cardiovascular prevention in overweight or obese patients  Marketing Authorisations   In a placebo-controlled trial in patients at high risk for cardiovascular events, their incidence was 1.5 percentage points lower in the injectable semaglutide group than in the placebo group, with no reduction in mortality and at a cost of frequent, and often troublesome, adverse effects. Full article available for download by subscribers 1 June 2024

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Recurring criticisms of Prescrire: how do we answer?   Outlook   Ever since Prescrire was launched in 1981, it has been criticised for its method of analysis, editorial process and certain editorial choices. This article addresses a few of the recurring criticisms levelled against Prescrire. Full article available for download by subscribers 1 June 2024

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Paternal exposure to valproate drugs in the period prior to conception: neurodevelopmental disorders in children?  Adverse Effects   In 2023, epidemiological data suggesting an increased incidence of neurodevelopmental disorders in children whose father had taken a valproate drug during the 3 months prior to conception led several drug regulatory agencies to issue alerts about this potential risk. As of early 2024, what are the main evaluation data concerning this risk, how strong is the evidence they provide, and to what extent should they be taken into account in clinical practice? Full article available for download by subscribers (3 pages) 1 June 2024

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ The finances of Association Mieux Prescrire: 2023 annual report   Outlook   Association Mieux Prescrire, the legal entity that publishes Prescrire's journals and continuing education programmes, makes its accounts public every year. The summary of its 2023 annual financial report is publicly available here. Full article available for download (free) 1 June 2024

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Enjoy these features, and more, in our upcoming issues COMING SOON• Spesolimab in generalised pustular psoriasis  • Dupilumab in prurigo nodularis • Methadone: an analysis of adverse effects • Regard for patients at the European Medicines Agency: myth or reality?  > Subscribe now 1 June 2024

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Covid-19: Follow Prescrire's independent, evidence-based analysis of the pandemic  COVID-19  Prescrire's editors are publishing an ongoing series of articles featuring independent analysis of developments related to the covid-19 pandemic. Useful and practical information, to help health professionals gain a clear and balanced view. 1 November 2023

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ New! "Top Texts of 2023", from the editors of Prescrire International  FREE SPECIAL EDITION  Check out this sampling of texts from Prescrire International, a wholly independent monthly drug bulletin, written by and for healthcare professionals. Inside, top articles from sections dedicated to new drugs authorised in Europe and key information on adverse drug effects, plus our annual update of drugs to avoid. > Click here for your free copy 1 August 2023

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Subscribe today for full access to top-quality content from Prescrire International  SUBSCRIBE NOW!  Enjoy access to subscriber-only content available on our website, including every article published in Prescrire International since 1992. Prices for a one-year subscription start at 165 euros (less for students and residents of lower-income countries). 1 January 2022

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Follow Prescrire International on Facebook and Twitter Keep up with the latest from Prescrire's editors, and support our values of independence and quality information, first and foremost in the interest of patients. Click here to > Follow us on Facebook or > Follow us on Twitter 1 January 2022

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Receive the free, monthly "Independent Drug & Healthcare Newsletter" Click here to sign up for the free Newsletter from the editors of the non-profit journal Prescrire International, with highlights of the contents of the latest issue. 1 July 2022

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Drugs to avoid, in the name of better patient care   DRUGS TO AVOID - 2024 UPDATE  Independent French medical journal Prescrire has published its annual update of drugs to avoid. The goal is to make it easier to choose high-quality care, and to prevent disproportionate harm to patients. > Read more

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Read more All the subjects in Prescrire's Spotlight >

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