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In Prescrire's Spotlight

Drugs to avoid in 2026  Editorial  Prescrire has published its fourteenth consecutive review of drugs to avoid. This annually updated review, with supporting references, identifies drugs that are more dangerous than beneficial in all the clinical situations in which they are authorised in France or in the European Union. Full article available for download (FREE) 1 February 2026

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Enfortumab vedotin (Padcev°) + pembrolizumab (Keytruda°) in unresectable or metastatic urothelial carcinoma  Marketing Authorisations  Enfortumab vedotin, a cytotoxic drug conjugated to an anti-nectin-4 monoclonal antibody, was already authorised for use as third-line treatment in locally advanced or metastatic urothelial cancer. It is now also authorised in first-line treatment in combination with pembrolizumab.  Full article available for download by subscribers 1 February 2026

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Sotatercept (Winrevair°) in pulmonary arterial hypertension  Marketing Authorisations  Sotatercept has been authorised in the European Union for use in adults with pulmonary arterial hypertension, as an add-on to other drugs. Does sotatercept extend survival in these patients? Does it reduce functional impairment and slow disease progression? And what are its adverse effects? Full article available for download by subscribers 1 February 2026

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Anabolic androgenic steroids: cardiac events and venous thromboembolism  Adverse effects  In 2025, a Danish team investigated the risk of cardiovascular disease in men who were attending fitness centres and taking anabolic androgenic steroids to enhance physical performance. Full article available for download by subscribers 1 February 2026

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ mRNA covid-19 vaccines: a review of adverse effects (continued)  Adverse effects  At the time of our literature search, in mid-2025, several reviews of reported adverse effects of mRNA covid-19 vaccines analysed by European and French drug regulatory agencies were available, with a follow-up of about 4.5 years. Full article available for download by subscribers 1 February 2026

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Drugs to avoid in the name of better patient care: 2026 update  DRUGS TO AVOID - 2026 UPDATE  To make it easier to choose high-quality care, and to prevent disproportionate harm to patients, Prescrire has published its annual update of drugs to avoid on the basis that they are more dangerous than beneficial. Full article (12 pages) available for download (FREE) 1 February 2026

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Enjoy these features, and more, in our upcoming issues COMING SOON• Bempedoic acid in cardiovascular prevention • Trastuzumab emtansine in breast cancer: new data • GLP-1 agonists during pregnancy • Drug shortages: proposed European legislation > Subscribe now 1 February 2026

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ New! "2025 Free Special Edition", from the editors of Prescrire International  FREE SPECIAL EDITION  Check out this selection of articles to introduce you to Prescrire International, a wholly independent monthly drug bulletin, written by and for healthcare professionals. Includes an array of articles from the past year on drugs and health policy in Europe. > Click here for your free copy 1 January 2025

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Subscribe today for full access to top-quality content from Prescrire International  SUBSCRIBE NOW!  Enjoy access to subscriber-only content available on our website, including every article published in Prescrire International since 1992. Prices for a one-year subscription start at 165 euros (less for students and residents of lower-income countries). 1 January 2022

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Follow Prescrire International on LinkedIn and Facebook Keep up with the latest from Prescrire's editors, and support our values of independence and quality information, first and foremost in the interest of patients. Click here to > Follow us on LinkedIn or > Follow us on Facebook 1 January 2025

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Receive the free, monthly "Independent Drug & Healthcare Newsletter" Click here to sign up for the free Newsletter from the editors of the non-profit journal Prescrire International, with highlights of the contents of the latest issue. 1 July 2022

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Drugs to avoid, in the name of better patient care   DRUGS TO AVOID - 2026 UPDATE  Independent French medical journal Prescrire has published its annual update of drugs to avoid. The goal is to make it easier to choose high-quality care, and to prevent disproportionate harm to patients. > Read more

¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯ Read more All the subjects in Prescrire's Spotlight >

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