english.prescrire.org > Prescrire International > N°113 - February 2011

n°113

February 2011

Issue Contents
Editorial

Free  With more follow-up

p.32
Calling initial assessments into question

New Products


Saxagliptin (type 2 diabetes) (New Drug)

p.33-37
No more effective than other gliptins, but a high potential for drug interactions

Imatinib (adjuvant therapy after surgical excision of gastrointestinal stromal tumour) (New Indication)

p.38
Too many unknowns

INN common stems : -trexed

p.38

Pemetrexed (maintenance therapy for non-small cell lung cancer) (New Indication)

p.39
Inadequately assessed, no proven advantages

Azacitidine (in myelodysplasia syndromes) (New Drug)

p.40
Promising, but more data needed

Adverse Effects


Drug-induced cataracts

p.41-43
Mostly corticosteroids, even after local or inhaled treatment

Drospirenone: high risk of venous thrombosis

p.43-45
Combined contraceptives: levonorgestrel and norethisterone are safer

Free  Benfluorex: how many deaths?

p.45
Pulmonary arterial hypertension and valve damage

Free  Dextropropoxyphene and cardiac disorders: new data

p.45
QT prolongation

Reviews


Adjuvant chemotherapy for localised colon cancer

p.46-49
Fluorouracil + folinic acid for node-positive, non-metastatic disease

Prescrire's advice: adjuvant treatment of colon cancer

p.49

Management of uncomplicated hypertension during pregnancy

p.50-51
ACE inhibitors, angiotensin II receptor blockers and aliskiren must be avoided

Prescrire's advice: management of uncomplicated hypertension during pregnancy

p.51

Outlook


Free  Treatment choices: specialist bias

p.52
Patients need access to balanced information

Free  Facing obstacles, yet doing one's job properly

p.53
A number of stakeholders are daring to do the right thing

Perseverance

p.54
Prescrire challenges the EMA's secrecy

Queries and comments : Activated charcoal adsorbs colchicine but does not replace gastric lavage

p.54

Free  Pharmacovigilance in Europe: some progress, but a missed opportunity

p.56

Masthead


Free  Masthead

p.30

The complete contents of 
this issue of Prescrire International
are available for download by
Prescrire International subscribers.
Certain texts are also available to
non-subscribers for free download,
as indicated. 

 

Subscribe