english.prescrire.org > Prescrire International > N°152 - September 2014

n°152

September 2014

Issue Contents
Editorial

Free  Repeating the same mistake

p.200
EMA approval of a second course of varenicline for smoking cessation is unfortunate

New Products


Meningococcal B vaccine (New Drug)

p.201-204
An immunogenic vaccine possibly useful during outbreaks

Development of meningococcal B vaccines

p.204

INN common stem: -gab

p.204

Aflibercept (New Drug)

p.205
Metastatic colorectal cancer: at least as poorly tolerated as bevacizumab

Free  Raltegravir in HIV-infected children at least 2 years of age (New Indication)

p.206
Only after prior treatment failure

Saxagliptin, alone or in combination (New Indication)

p.207
No fewer complications; more cases of heart failure?

Smoking cessation and varenicline

p.208
Do not expose or re-expose patients to its serious adverse effects!

Adverse Effects


Crushing tablets or opening capsules: many uncertainties, some established dangers

p.209-214
Consider and research the impact on the drug's effects

Before crushing a tablet or opening a capsule

p.211

Oral dosage forms

p.212-213

Temozolomide: fatal hepatic failure

p.214
Check liver function tests

Atazanavir: urolithiasis

p.214
Patients need to be briefed

Reviews


Treating essential hypertension

p.215-220
The first choice is usually a thiazide diuretic

The treatment threshold for hypertension

p.219

Editors' Advice

p.220
Antihypertensive treatment for adults without diabetes or cardiovascular or renal disease

Outlook


Free  Health info in doctors' waiting rooms: be selective!

p.221
A survey by a French consumer group

PCB pollutants: reduce consumption of some freshwater fish

p.222-223
Women of child-bearing age, pregnant or breastfeeding women, children under 3, are particularly at risk

Masthead


Free  Masthead

p.198

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