english.prescrire.org > Prescrire International > N°198 - November 2018

n°198

November 2018

Issue Contents
Editorial

Free  Health technology assessment: an EU draft to be amended

p.255

New Products


Canakinumab (Ilaris°) and periodic fever syndromes

p.257-259
Effective against symptoms, but no long-term evaluation

Venetoclax (Venclyxto°) and chronic lymphocytic leukaemia

p.259-260
Premature marketing authorisation

Lopinavir + ritonavir oral solution (Kaletra°) from 14 days of age

p.260-261

Inotuzumab ozogamicin (Besponsa°) and acute ­lymphoblastic leukaemia in adults

p.261
Higher transplant rate, but fatal adverse effects

Atezolizumab (Tecentriq°) and metastatic or inoperable lung cancer

p.262
Very similar to nivolumab

Adverse Effects


Drug-induced gynaecomastia

p.263-266

Inset. Drug-induced galactorrhoea

p.264

High-dose baclofen and alcohol dependence: hospitalisations and deaths

p.266-268

Denosumab: immune dysfunction

p.268-269

Inset. Denosumab: multiple vertebral fractures after discontinuation

p.269

Ulipristal: fulminant hepatitis

p.270

Clarithromycin in patients with coronary heart disease: excess mortality in the long term

p.270

Reviews


Desensitisation in seasonal allergic rhinitis

p.271
Too many harms and too little efficacy

Pain due to acute otitis media in children

p.272-273
Paracetamol alone is the first choice

Prevention of cardiovascular disease in diabetes

p.274
Aspirin as primary prevention: a narrow margin between benefits and harms

"Targeted therapies" for metastatic colorectal cancer

p.274-275
A weak or uncertain effect on survival, with a risk of serious adverse effects

Postcoital contraception: is ulipristal more effective than levonorgestrel?

p.275-276

Outlook


Free  Vaccines and drugs: unacceptable shortages

p.277

Free  Ending pharmaceutical sales representatives' access to hospitals and students

p.278-279

Masthead


Free  Masthead

p.254

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