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Covid-19: Follow Prescrire's independent, evidence-based analysis of the pandemic

 COVID-19  Prescrire's editors are publishing an ongoing series of articles featuring independent analysis of developments related to the covid-19 pandemic. Useful and practical information, to help health professionals gain a clear and balanced view.

  • Remdesivir (Veklury°) in covid-19 at increased risk of progression to severe disease, or in children on oxygen (November 2023) > HERE
  • Recombinant Beta variant covid-19 vaccine with adjuvant (Vidprevtyn Beta°), as a booster (June 2023) > HERE
  • Omicron variant BQ.1.1: nirmatrelvir + ritonavir retains activity, monoclonal antibodies do not (April 2023) > HERE

  • Nirmatrelvir + ritonavir (paxlovid°) in covid-19: probably also useful when the Omicron variant is predominant (January  2023) > Pdf, subscribers only
  • Bivalent mRNA covid-19 vaccines that also target the Omicron variant: more antibodies (December 2022) > HERE
  • Messenger RNA covid-19 vaccines: an update on adverse effects (November 2022) > HERE
  • Viral vector covid-19 vaccines authorised in the European Union: a review of their adverse effects  (October 2022) > HERE
  • An African covid-19 vaccine, despite foot-dragging by drug companies  (October 2022) > HERE
  • Tixagevimab + cilgavimab (Evusheld°) in the prevention of covid-19 > Pdf, subscribers only
  • Covid-19: delays in other types of health care (July 2022) > HERE
  • Nirmatrelvir + ritonavir (Paxlovid°) in covid-19, for certain patients at risk of developing severe disease (June 2022) > HERE
  • Messenger RNA covid-19 vaccines tozinameran (Comirnaty°) and elasomeran (Spikevax°) during pregnancy (June 2022) > HERE

  • NVX-CoV2373 (Nuvaxovid°) in the prevention of covid-19 in adults. Effective for at least 3 months, but no proven efficacy against the Omicron variant (June 2022) > Pdf, subscribers only
  • Casirivimab + imdevimab (Ronapreve°) in early covid-19 (May 2022) > Pdf, subscribers only

  • Molnupiravir (Lagevrio°) in early covid-19 (May 2022) > Pdf, subscribers only
  • Tozinameran (Comirnaty°) and covid-19 in adolescents (April 2022) > Pdf, subscribers only

  • Tozinameran (Comirnaty°) and covid-19 from 5 to 11 years of age (April 2022) > Pdf, subscribers only
  • Elasomeran (Spikevax°) and covid-19 in adolescents (April 2022) > Pdf, subscribers only

  • Colchicine and covid-19 warranting hospitalisation: not worth the risk (April 2022) > Pdf, subscribers only
  • "Covid-19 vaccine booster dose: demonstrated clinical efficacy during Delta variant predominance, and no new safety signals" (March 2022) > Pdf, subscribers only
  • "Molnupiravir and early covid-19 without signs of severe illness: value uncertain, including in unvaccinated patients at risk of exacerbation" (March 2022) > Pdf, subscribers only
  • "Update on myocarditis linked to the covid-19 messenger RNA vaccines tozinameran (Comirnaty°) and elasomeran (Spikevax°)" (February 2022) > HERE

  • "Covid-19 vaccines : good for business too" (February 2022) > HERE
  • "Casirivimab + imdevimab (Ronapreve°) in early covid-19 with no signs of severity: possibly useful in patients at high risk of developing severe covid-19" (January 2022) > Pdf, subscribers only
  • Covid-19 vaccine booster dose: great uncertainty over its value in the general population (November 2021) > HERE
  • Known Adverse effects of messenger RNA covid-19 vaccines as of mid-2021 (November 2021) > HERE
  • "The Sars-CoV-2 Delta variant: how effective are covid-19 vaccines against this strain?" (October 2021) > HERE

  • "Covid-19 vaccines: glaring inequality" (October 2021) > HERE
  • "Viral vector covid-19 vaccine ChAdOx1-S (Vaxzevria°) and covid-19. Efficacy in the short term, but a risk of rare, sometimes fatal, thrombosis" (September 2021) > HERE
  • "Covid-19 drugs and vaccines: big money and winning alliances" (June 2021) > HERE
  • "Waste in covid-19 clinical trials" (June 2021) > HERE
  • "Covid-19 vaccine Ad26.CoV2S (by Janssen): as with the other covid-19 vaccines, effective in the short term but unknowns remain" (23 March 2021) > HERE
  • "The AstraZeneca covid-19 vaccine: British epidemiological data on the vaccination of older adults, and reassuring pharmacovigilance data" (15 March 2021) > HERE

  • "Messenger RNA covid-19 vaccines: Prescrire's in-depth analysis as of end February 2021 (2 March 2021) > HERE

  • "Covid-19 and ivermectin: many trials, few results, no proven efficacy " (13 February 2021) > HERE

  • "The ChAdOx1 nCoV-19 covid-19 vaccine from AstraZeneca: great uncertainty over its efficacy" (29 January 2021) > HERE

  • "The covid-19 messenger RNA vaccine from Moderna: as with the tozinameran vaccine (Comirnaty°, Pfizer/BioNTech), limited data and unanswered questions" (6 January 2021) > HERE
  • "The covid-19 messenger RNA vaccine tozinameran (Comirnaty°, from Pfizer and BioNTech) in elderly patients: limited data, many uncertainties" (23 December 2020) > HERE
  • "Covid-19 and vitamin D: too uncertain" (15 December 2020) > HERE
  • "Evaluation of covid-19 vaccines: the questions to ask" (20 November 2020) > HERE
  • "Covid-19 patients who are not hospitalised: anticoagulation is rarely justified" (24 September 2020) > HERE
  • "Proton pump inhibitors: increased risk of severe covid-19" (15 September 2020) > HERE
  • "Hydroxychloroquine in covid-19: no proven efficacy, including in less severe forms of the disease" (24 July 2020) > HERE
  • "Covid-19: remdesivir (Veklury°) authorised in the European Union, yet much remains unknown or uncertain" (13 July 2020) > HERE
  • "Covid-19 and severe breathing problems: dexamethasone reduced mortality in one trial" (24 June 2020) > HERE
  • "Lack of access to drug evaluation data: a recurrent problem, not confined to covid-19" (8 June 2020) > HERE
  • "Covid-19 and hydroxychloroquine (Plaquenil°): new data show no evidence of efficacy"  (16 April 2020) > HERE
  • "New data on the cardiac adverse effects of the combination of hydroxychloroquine (Plaquenil°) with azithromycin (Zithromax° or other brands)" (16 April 2020) > HERE

  • "Covid-19 and hydroxychloroquine (Plaquenil°): still no conclusive results" (15 April 2020) > HERE

  • "Covid-19 and hydroxychloroquine: uncertainties and unanswered questions" (2 April 2020) > HERE

  • "Covid-19 and hydroxychloroquine: caution" (30 March 2020) > HERE
  • "Covid-19 and drug trials: what to make of the initial results?" (23 March 2020) > HERE

  • For more information in French, see www.prescrire.org:
    > Covid-19. Année 2022. Des informations fiables et utiles

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