english.prescrire.org > Prescrire International > N°101 - June 2009

n°101

June 2009

Issue Contents
Editorial

Free  Sending the wrong signals

p.96
Orlistat without a prescription in the EU

Marketing Authorisations

Dabigatran (thromboembolism prophylaxis) (New Drug)

p.97-100
Heparin is a better-known option

Different classes of anticoagulants

p.99

Orlistat without a prescription (excess body weight) (New Status)

p.101
Often uncomfortable and don't expect miracles

Etravirine (multidrug-resistant HIV) (New Drug)

p.102-103
Another option

Atazanavir (HIV infection) (New Indication)

p.104
Nothing new for first-line therapy

Efavirenz + emtricitabine + tenofovir (HIV infection) (New Combination)

p.105
Do not modify ongoing therapy

Docosanol (herpes labialis) (New Drug)

p.106-107
Barely more effective than an excipient

Certolizumab pegol (Crohn's disease) (New Drug)

p.108-110
Not acceptable

Fentanyl transdermal system (postoperative analgesia) (Market Withdrawal)

p.110
Market withdrawal in the EU

Mecasermin (children with IGF-1 deficiency) (New Drug)

p.111-113
Insufficient improvement in statural growth

Atovaquone + proguanil (children 5 kg or more) (New Indication)

p.113
Inconvenient form

Pemetrexed (untreated non-small cell lung-cancer) (New Indication)

p.114
Just another cytotoxic drug

Ramelteon (insomnia) (Application Withdrawn)

p.114
EU Marketing application withdrawn

Sitagliptin + metformin (type 2 diabetes)

p.115
Do not use this combination

Tenofovir (chronic hepatitis B) (New Indication)

p.116
Beware bone toxicity

Aripiprazole (maniac episodes) (New Indication)

p.117
Lithium remains the standard drug

INN common stems : -porfin

p.118

INN common stems : -racetam

p.118

Urokinase (thrombosed venous catheters) (New Indication)

p.118
When heparin fails

Adverse Effects

Drug-induced sialorrhoea and excessive saliva accumulation

p.119-121

Intravenous paracetamol and arterial hypotension

p.121

Gemcitabine: cutaneous, hepatic and vascular disorders

p.122

Topical tacrolimus and cancer (continued)

p.122

Free  Corticosteroids: neuropsychiatric effects in children and adolescents

p.123

Free  Mydriatric eye drops: severe adverse effects in children

p.123

Free  Sitagliptin: serious allergies

p.123

Exenatide: renal failure

p.124

BCG SSI°: adverse effects still reported

p.124

Free  Benfluorex: negative data in France, but still on the market

p.124

Reviews

Intrauterine devices

p.125-130
An effective alternative to oral hormonal contraception

Postcoital contraception with an IUD

p.128

IUDs and pelvic infections

p.129

Continue to vaccinate against hepatitis B

p.131

Outlook

Free  The finances of Association Mieux Prescrire 2008 Prescrire annual report

p.132-133

Free  Drug packaging in 2008

p.134-135

Counterfeit drugs: recognising the real issues

p.135

NSAID-free pregnancies: a Prescrire professional programme

p.136-138

NSAID-free pregnancies: a Prescrire training goal

p.137

Other Prescrire programmes

p.138

Free  Welcome to the new website: Prescrire in English

p.140

Masthead

Free  Masthead

p.94

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