n°117

June 2011

Issue Contents
Editorial

Free  The sledgehammer

p.144
Risky approval of denosumab

Marketing Authorisations

Denosumab (New Drug)

p.145-148
Limited efficacy in fracture prevention, too many adverse effects

Docetaxel and adjuvant treatment of breast cancer (New Indication)

p.149
Data manipulation: not acceptable

Telmisartan in high-risk cardiovascular patients (New Indication)

p.150
No need to change standard practice

INN common stem: -fibrate

p.150

Intravenous moxifloxacin (New Form)

p.151
Even more harmful than the oral form

Adverse Effects

To treat or not to treat cancer patients with chemotherapy at the end of life?

p.152-153
A British study of 600 cases

Somatropin: increased mortality?

p.153
The risk should be discussed before prescribing

Strontium ranelate: too many adverse effects

p.154
Definitely a do-not-use drug

Adjuvant-containing H1N1 influenza vaccine Pandemrix°: narcolepsy in children

p.154
Watch this space

Fenofibrate: altered renal function

p.154-155
Gemfibrozil a safer fibrate

Free  Bevacizumab, sunitinib: osteonecrosis of the jaw

p.155
Beware invasive dental procedures

Free  Fluoxetine in early pregnancy: cardiac birth defects

p.155
Caution advised with all SSRIs

Free  Venous sclerosants: distant ischaemic disorders

p.155
Dozens of reports

Reviews

Acute heart failure with dyspnoea: initial treatment

p.156-160
Furosemide and trinitrine, despite the lack of a proven survival benefit

Lambert-Eaton myasthenic syndrome in brief

p.161
Management mostly based on the triggering malignancy

Outlook

Free  2010 drug packaging review. Identifying problems to prevent errors

p.162-165
Potentially dangerous packaging remains a significant problem

Free  Editors' opinion: Regulatory agencies and companies must take packaging more seriously

p.165

Control of drug advertising in France: opaque and ineffective

p.166
Failure of prepublication controls

Even when regulated, advertising is still advertising

p.166
A Swiss study

Free  Free content online

p.168

Masthead

Free  Masthead

p.142

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