english.prescrire.org > Prescrire International > N°135 - February 2013

n°135

February 2013

Issue Contents
Editorial

Free  Malfeasance on an industrial scale

p.32
Pharmacovigilance is mission impossible for pharmaceutical companies

Marketing Authorisations

Argatroban (Additional Market Launch)

p.33-35
For a few selected patients

INN common stem: -oxacin

p.35

Linagliptin (New Drug)

p.36-37
Avoid gliptins!

Prescrire's advice

p.37
Do not include gliptins in your prescribing list

13-valent pneumococcal vaccine: 50 years of age and older (New Indication)

p.38
No proven benefit

Neoadjuvant trastuzumab for breast cancer (New Indication)

p.39
Better to stick with proven treatments

Saxagliptin + metformin (New Combination)

p.40
Mostly disadvantages

Adverse Effects

Dabigatran: life-threatening bleeding

p.41-43
Pharmacovigilance revealed risk factors

SSRI antidepressants: altered psychomotor development following exposure in utero?

p.43-44
During pregnancy non-drug methods should be tried first

Injectable paracetamol in children: yet more cases of 10-fold overdose

p.44-45
Do not mix milligrams and millilitres

Benfluorex: in utero exposure

p.46
Women were given appetite suppressants during pregnancy

Intravenous administration: frequent errors

p.46
Mostly faster administration rate

Everolimus: gastrointestinal haemorrhage

p.46
List of adverse effects growing

Free  An initiative to prevent the adverse effects of metformin

p.47
A collaborative approach

Free  Methylphenidate: abuse in Europe

p.47
Alarming increase in consumption

Free  Benfluorex and cardiac valve disease: long delay in publication

p.47
Unresponsive authorities

Reviews

First-line treatment of metastatic prostate cancer

p.48-51
Androgen suppression for symptomatic disease

Choice of first-line treatment for metastatic prostate cancer

p.51

Outlook

Drugs in wastewater: incomplete removal by treatment plants

p.52-54
One more reason to reduce drug use

The European Union Water Framework Directive (2000)

p.53

The important role of public-sector research in the United States

p.54
A key contributor to the development of new drugs

(Hi)story

p.55
Ceruse: a skin-lightening cosmetic at the king's court

Masthead

Free  Masthead

p.30

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