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n°135

February 2013

Prescrire International

Issue Contents

Editorial
Free Malfeasance on an industrial scale	p.32
Pharmacovigilance is mission impossible for pharmaceutical companies

Marketing Authorisations
Argatroban (Additional Market Launch)	p.33-35
For a few selected patients


INN common stem: -oxacin	p.35


Linagliptin (New Drug)	p.36-37
Avoid gliptins!


Prescrire's advice	p.37
Do not include gliptins in your prescribing list


13-valent pneumococcal vaccine: 50 years of age and older (New Indication)	p.38
No proven benefit


Neoadjuvant trastuzumab for breast cancer (New Indication)	p.39
Better to stick with proven treatments


Saxagliptin + metformin (New Combination)	p.40
Mostly disadvantages

Adverse Effects
Dabigatran: life-threatening bleeding	p.41-43
Pharmacovigilance revealed risk factors


SSRI antidepressants: altered psychomotor development following exposure in utero?	p.43-44
During pregnancy non-drug methods should be tried first


Injectable paracetamol in children: yet more cases of 10-fold overdose	p.44-45
Do not mix milligrams and millilitres


Benfluorex: in utero exposure	p.46
Women were given appetite suppressants during pregnancy


Intravenous administration: frequent errors	p.46
Mostly faster administration rate


Everolimus: gastrointestinal haemorrhage	p.46
List of adverse effects growing


Free An initiative to prevent the adverse effects of metformin	p.47
A collaborative approach


Free Methylphenidate: abuse in Europe	p.47
Alarming increase in consumption


Free Benfluorex and cardiac valve disease: long delay in publication	p.47
Unresponsive authorities

Reviews
First-line treatment of metastatic prostate cancer	p.48-51
Androgen suppression for symptomatic disease


Choice of first-line treatment for metastatic prostate cancer	p.51

Outlook
Drugs in wastewater: incomplete removal by treatment plants	p.52-54
One more reason to reduce drug use


The European Union Water Framework Directive (2000)	p.53


The important role of public-sector research in the United States	p.54
A key contributor to the development of new drugs


(Hi)story	p.55
Ceruse: a skin-lightening cosmetic at the king's court

Masthead
Free Masthead	p.30

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