n°138

May 2013

Issue Contents
Editorial

Free  Research scientists: endemic fraud

p.116
Unscrupulous pursuit of gain

Marketing Authorisations

Pirfenidone (New Drug)

p.117-119
First, do no harm

Free  Panitumumab adjunctive therapy (New Indications)

p.120
No place in either first- or second-line treatment of metastasic colorectal cancer

Vildagliptin monotherapy (New Indication)

p.121
To be avoided, like other DPP-4 inhibitors

INN common stem: -renone

p.121

INN common stem: -cycline

p.121

Tegafur + gimeracil + oteracil (New Drug)

p.122
Just another fluorouracil percursor

Adverse Effects

Anaphylactic reactions during anaesthesia: neuromuscular blocking agents, latex and antibiotics

p.123-124
Avoid unecessary exposure to latex

Heparin-induced thrombocytopenia

p.124-125
To be weighed in the harm-benefit balance

Weekly oral methotrexate therapy: raise awareness of fatal dosing errors

p.126
Packaging must be improved

Fatal methotrexate overdose

p.126
A case reported to Prescrire's Preventing the Preventable programme

Mephenesin: abuse and dependence

p.127-128
Do not use this muscle relaxant

Risperidone: rhabdomyolysis

p.128
Sometimes without malignant syndrome

Bisphosphonates: uveitis and scleritis

p.128
Better to warn patients

Dabigatran and mechanical valves:less effective and more risky than warfarin

p.128
Vitamin K antagonists first

Reviews

Deep venous thrombosis and pulmonary embolism

p.129-133
Prevention of recurrences

Prescrire's advice

p.131
Choosing a treatment for deep venous thrombosis and pulmonary embolism

Botulinum toxin type A and tension-type headache

p.133
Unfavourable harm-benefit balance

Outlook

Free  2012 drug packaging review: many dangerous, reportable flaws

p.134-137
Health professionals should report dangerous packaging

Free  Prescrire's packaging analysis

p.135

Exceptions to and deviations from the INN common stem system

p.138-139
To avoid pitfalls and misunderstandings

The FDA is spying on whistleblowers

p.139
Public health is at stake

Masthead

Free  Masthead

p.114

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