english.prescrire.org > Prescrire International > N°184 - July 2017

n°184

July 2017

Issue Contents
Editorial

Free  The sorcerer's apprentice

p.171

New Products

Safinamide (Xadago°) and Parkinson's disease with motor fluctuations

p.173-176
Just another MAO-B inhibitor with no proven advantages

Pertuzumab (Perjeta°) before breast cancer surgery

p.176-177
Co-administered with trastuzumab: no benefit but more adverse effects

Pertuzumab (Perjeta°) and metastatic breast cancer

p.178-179
Longer survival confirmed, but cardiac risks to be monitored

INN Common stem: -ifene, -mifene, -oxifene

p.179

Equine oestrogens + bazedoxifene (Duavive°) and menopause

p.180-182
Inadequately evaluated harms

Adverse Effects

Varenicline and neuropsychiatric disorders: caution, despite the Eagles trial abstract

p.183-185

Aliskiren: withdrawal of reimbursement in sight

p.185

Benfluorex: aortic and mitral stenosis as well

p.185

Ambroxol mouth spray: a drug to avoid

p.186

Rivaroxaban: agranulocytosis and Stevens-Johnson syndrome

p.186

Free  Temsirolimus: risk of myocardial infarction

p.187

Free  Pholcodine: anaphylactic reactions to neuro­muscular blockers

p.187

Reviews

Graves' disease during pregnancy

p.188-192
Treatment is problematic

Fetal risks associated with Graves' disease during pregnancy

p.190

Other thyroid disorders during pregnancy

p.191

Radioactive iodine: dangerous for the fetus

p.192

Outlook

Market withdrawal due to adverse effects: frequent but often belated

p.193-195

Drugs with fatal adverse effects: left on the market too long

p.195

Masthead

Free  Masthead

p.170

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