english.prescrire.org > Prescrire International > N°222 - January 2021

n°222

January 2021

Issue Contents
Editorial

Free  A two-step approach

p.3

New Products


Esketamine (Spravato°) and "treatment-resistant" depression

p.5-9
Huge risks for uncertain efficacy

Editors' opinion. Misuse

p.8

Tafamidis (Vyndaqel°) and transthyretin amyloid cardiomyopathy

p.9-10

Voretigene neparvovec (Luxturna°) and certain forms of inherited retinal dystrophy

p.10-11
Improvement in navigational ability in dim light, but questions remain over the risks

INN Common stem: -steride

p.11

Free  Dasatinib (Sprycel° and other brands) in children with acute lymphoblastic leukaemia

p.12-13

Free  Editors' opinion. Failure to demand solid evidence for marketing authorisation spells danger for patients

p.13

Risankizumab (Skyrizi°) and plaque psoriasis

p.13

Romiplostim (Nplate°) and chronic immune thrombocytopenia from one year of age

p.13

Remdesivir (Veklury°) and covid-19

p.14-15
Too many uncertainties over its efficacy as well as its harms

Editors' opinion. Authorisation of remdesivir in the European Union: EMA needs to prioritise patients' interests

p.15

Adverse Effects


SSRI antidepressants and pregnancy: long-term neuropsychiatric disorders in exposed children? (continued)

p.16-18

Lamotrigine: very variable exposure in breastfed infants

p.19

NSAIDs: complications of sinusitis

p.19

Reviews


 Queries and Comments. Erythema migrans: what is the first-choice antibiotic?

p.20

Psoriatic arthritis and secukinumab

p.21
No better than adalimumab, and with more limited follow-up

Gout attack pain

p.22
Colchicine no more effective than naproxen

Outlook


 History(ies). The invention of antidepressants

p.23-25

Adverse effects and clinical trial results in oncology: misleading terms and omissions

p.26-27

Drug research and development: public investors with an ambivalent role

p.27

Masthead


Free  Masthead

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