english.prescrire.org > Prescrire International > N°225 - April 2021

n°225

April 2021

Issue Contents
Editorial

Free  40 years

p.87

Marketing Authorisations


Larotrectinib (Vitrakvi°) and cancers with an NTRK gene fusion

p.89-91
Grossly inadequate evaluation as of early 2021

Editors' opinion. Dissuasion

p.90

INN Common stem: -taxel

p.91

Insulin lispro with treprostinil and sodium citrate as excipients (Lyumjev°)

p.92-93

Trastuzumab emtansine (Kadcyla°) for certain breast cancers, after surgery

p.93

Quadrivalent influenza vaccine containing 60 micro­grams per strain (Efluelda°) in the elderly

p.93

Atezolizumab (Tecentriq°) and certain small cell lung cancers

p.94

Atezolizumab (Tecentriq°) and inoperable or metastatic triple-negative breast cancer

p.95

Adverse Effects


Valproic acid: is it an endocrine disruptor?

p.96-100

Inset. Endocrine-disrupting drugs: their main effects on human hormone systems

p.98-99

Paclitaxel: peripheral neuropathy sometimes persisting more than 12 months

p.101

Lenograstim: venous and arterial thromboembolism

p.101

Ivermectin: coma in a child

p.102

Memantine: bradyarrhythmia

p.102

Vaginal progesterone: intrahepatic cholestasis of pregnancy

p.103

Queries and Comments. Food supplements: should consumers be reassured?

p.104

Reviews


Inset. Pomalidomide (Imnovid°) and multiple myeloma, after failure of lenalidomide

p.105

Relapsed or refractory multiple myeloma

p.105-106

Covid-19 and vitamin D: too uncertain

p.106

Free  Hydrochlorothiazide in hypertension

p.107
An accept­able first choice

Outlook


Free  Drugs in 2020: a brief review

p.108-109

Drug shortages: a (big) thorn in the side of pharma­cists

p.109

Free  Mediator°: norfenfluramine at the heart of the trial

p.110

Ulipristal (Esmya°): reintroduction to the market would be reckless

p.111

Sodium oxybate in alcohol dependence: marketing authorisation refused

p.111

Masthead


Free  Masthead

p.86

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