english.prescrire.org > Prescrire International > N°244 - January 2023

n°244

January 2023

Issue Contents
Editorial

Free  Revolving door between the public and private sectors: conflict of interest

p.3

Marketing Authorisations

Relugolix + estradiol + norethisterone (Ryeqo°) in uterine fibroids

p.5-8
A risky hormone cocktail

Editors' opinion. Cascade

p.6

Setmelanotide (Imcivree°) in certain, very rare, genetic forms of obesity

p.9-11
Reduced hunger and body weight, but its other benefits and harms are uncertain

Nirmatrelvir + ritonavir (Paxlovid°) in covid-19: probably also useful when the Omicron variant is predominant

p.11

Azacitidine tablets (Onureg°) for "maintenance" therapy in acute myeloid leukaemia

p.12-13

Pitolisant (Ozawade°) in excessive daytime sleepiness linked to sleep apnoea

p.13

Cenobamate (Ontozry°) in focal seizures

p.14

Pembrolizumab (Keytruda°) in certain inoperable or metastatic triple-negative breast cancers

p.14

Smallpox vaccine (Imvanex°) and monkeypox: used in summer 2022 without clinical evaluation

p.15

Glecaprevir + pibrentasvir (Maviret°) for hepatitis C from 3 years of age

p.16

Carfilzomib (Kyprolis°) + daratumumab + dexamethasone in multiple myeloma from the second line of treatment

p.17

Isatuximab (Sarclisa°) + carfilzomib + dexamethasone in multiple myeloma from the second line of treatment

p.17

Ixekizumab (Taltz°) for plaque psoriasis in children and adolescents

p.18

Adverse Effects

Benzodiazepines: acute angle-closure glaucoma

p.19

Oral cladribine: liver injury

p.20

GLP-1 agonists such as liraglutide: gallstones and cholecystitis

p.20

Infliximab during pregnancy: fatal BCG infections in infants

p.21

Trimebutine: too many cardiac risks

p.21

Tocilizumab: gastric perforation

p.22

Common stem: -virine

p.22

Outlook

Free  Impending changes to European pharmaceutical regulations

p.23-25
Part II. The European Parliamentary Research Service in favour of a European Medicines Infrastructure

Drug companies required to declare public funds received for research and development

p.26

Amfepramone: withdrawal from the European market delayed

p.26-27

The methodology of new types of clinical trials

p.27

Masthead

Free  Masthead

p.2

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