Free  Interdisciplinary collaboration

Marketing Authorisations

Daridorexant (Quviviq°) in insomnia

Editors' opinion. New is not necessarily better

Mepolizumab (Nucala°) in nasal polyposis

Lenvatinib (Lenvima°) + pembrolizumab (Keytruda°) in advanced or relapsed endometrial cancer

Ozanimod (Zeposia°) in ulcerative colitis

Eptinezumab (Vyepti°) for prevention of migraine attacks

Daratumumab (Darzalex°) in systemic light chain amyloidosis

Ustekinumab in Crohn's disease

Secukinumab (Cosentyx°) in some types of juvenile arthritis

Doravirine alone (Pifeltro°) or in combination (Delstrigo°) for HIV infection in adolescents

Niraparib in ovarian cancer: indications restricted in the US, a measure also warranted in the EU

Adverse Effects

Venlafaxine during the first trimester of pregnancy: possible risk of birth defects, especially cardiac malformations

Sclerosants for varicose veins: thrombo­embolism and cardiac arrhythmias

Ibuprofen + codeine in the same tablet: fatal renal and gastro­intestinal adverse effects

Diltiazem + a direct-acting anti­coagulant: serious bleeding

Common stem: -kef-

Outlook

"Hybrid closed-loop" systems for blood glucose control in type 1 diabetes

Inset. What are hybrid closed-loop systems for blood glucose control, and how do they work?

The evaluation of drugs to treat type 2 diabetes

Free  Clinical trials in children: many results go unreported

Masthead

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