Free  Safety signals: why bother?

Marketing Authorisations

Abemaciclib (Verzenios°), palbociclib (Ibrance°) and ribociclib (Kisqali°) added to an aromatase inhibitor in certain breast cancers

20-valent pneumococcal conjugate vaccine (Apexxnar°) in adults

Eladocagene exuparvovec (Upstaza°) in aromatic L-amino acid decarboxylase deficiency

Axicabtagene ciloleucel (Yescarta°) as second-line treatment in certain B-cell lymphomas

Abemaciclib (Verzenios°) + endocrine therapy as adjuvant treatment in certain early-stage breast cancers

Atezolizumab (Tecentriq°) as adjuvant treatment for certain non-small cell lung cancers

Covid-19 vaccine raxtozinameran (Comirnaty Omicron XBB.1.5°)

Covid-19 messenger RNA vaccines for children aged 6 months to 5 years

Axicabtagene ciloleucel (Yescarta°) as fourth- or subsequent-line therapy for follicular lymphoma

Adverse Effects

Phloroglucinol during pregnancy: poorly defined risks

Prescribing cascades: recognise them and take corrective action

Nitrofurantoin: acute hepatitis and acute respiratory failure

Levonorgestrel-releasing intrauterine devices: depression

Xabans: interstitial lung disease (continued)

Methylphenidate: myocardial infarction in a child

Common stem: nal-

Outlook

When to take a safety signal into account: Prescrire's experience

When the cause of a disorder is not immediately obvious: could a drug be responsible?

Free  Defending the right to compensation for the victims of drug-induced harms

Belgium: conflicts of interest within the Drug Reimbursement Committee

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