n°4

December 1992

Issue Contents
Editorial

Europe must adopt orphan drugs

p.145-146

Marketing Authorisations


Colfosceril palmitate freeze-dried powder and solution for intratracheal instillation

p.147-149

Several surfactants

p.149

Lodoxamide eye- preparation

p.149-150

Nicotine transdermal patches

p.150-152

Nicotine skin patches are incompatible with smoking

p.152

Filgrastim (G-CSF) solution for injection

p.153-155

G-CSF and haematopoiesis

p.154

Recombinant interleukin-2 preparation for injection

p.155-156

Granisetron solution for infusion

p.157-158

Alpha interferons and chronic active non-A, non-B hepatitis in adults

p.159-161

Non-A, non-B hepatitis

p.160

Beta-alanine, a 400 mg placebo?

p.161

Foaming ketoconazole gel for seborrhoeic dermatitis

p.162-163

Single-dose local ketoconazole for pityriasis versicolor

p.164

Injectable folinic acid with 5-fluorouracil

p.165

Adverse Effects


Glucocorticoid-induced osteoporosis

p.167

Long-term sequelae of hexachlorophene poisoning

p.168

Hepatitis due to disulfiram

p.169

Fatal side-effects

p.169

Rare allergic reactions to corticosteroid injections

p.170-171

Adverse effects of dapsone

p.171-172

Cramp, quinine and thrombocytopenia

p.172

Allergic reactions to injectable benzathine penicillin

p.173

Drug hepatotoxicity can be dose-dependent

p.173

Reviews


No reason to keep dipyridamole on the market

p.174-176

Generics: neither angels nor demons

p.176-179

The simplified marketing procedure

p.178

Toxic epidermal necrolysis

p.180-182

Cutaneous reactions other than Lyell's syndrome

p.182

Helicobacter superstar

p.183

Stroke prevention by anticoagulants in patients with atrial fibrillation

p.184-185

The force of prejudice

p.186

Outlook


Data please!

p.184

Information or disinformation?

p.185-186

Drugs and breast-feeding

p.187

Drugs and plastic infusion packs

p.188

Electroconvulsive therapy

p.188

Fraudulent Nivaquine°

p.188

Low-cost generics

p.188-189

Breast milk expanders

p.189

Cancer and fringe medicine

p.189

Sports doping

p.189

Forum


Hazards of antimotility drugs

p.190

Anistreplase (continued)

p.190

Malaria: clothes too!

p.191

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