n°57

February 2002

Issue Contents
Editorial

Some statins are more equal than others

p.2

Marketing Authorisations

Clozapine: a last resort for Parkinsonian patients with psychosis

p.3-6

Which neuroleptics in Parkinson's disease? Difficult compromise between adverse effects

p.5-6

7-valent pneumococcal conjugate vaccine: prevents rare invasive infections in infants

p.7-10

Orlistat: at best, a minor adjunct to dietary measures

p.10-12

Tinzaparin: easier treatment of less severe pulmonary embolism

p.13-15

Treatment of pulmonary embolism: a few days on heparin, then several months on a vitamin K antagonist

p.14-15

Liposomal doxorubicin: no progress in advanced ovarian cancer

p.29

Brinzolamide eye drops: a me-too anhydrase inhibitor for chronic glaucoma

p.29-30

Albendazole in trichinosis: limited assessment

p.30

Bisoprolol and chronic heart failure: reduces mortality like carvedilol

p.30

Paclitaxel: as an adjunct to surgery for advanced ovarian cancer

p.30

Adverse Effects

Drugs can trigger pathological gambling

p.16

Severe liver damage on terbinafine

p.16

Drugs and breast-feeding

p.17

Severe adverse effects of non specific "immunotherapy"

p.21

Highlights of the 22nd French pharmacovigilance meeting

p.21-23

Sleep attacks and antiparkinsonian drugs

p.22

Headache induced by analgesics and migraine drugs

p.22

Bleeding due to tramadol interaction with oral anticoagulants

p.22

Follow up on the safety of methylphenidate

p.22

Hyperkalaemia induced by the combination of spironolactone and an ACE inhibitor

p.22

Flecainide and interstitial pneumonia

p.22-23

Reviews

Simple febrile convulsions in children: explain and reassure the parents

p.18-20

Management of advanced-stage ovarian cancer

p.24-25

Outlook

Drug packaging: safety and convenience above all

p.26-27

FDA

p.28

Medwatch: the FDA safety information adverse effect reporting program

p.29

International society of drug bulletins (ISDB), Paris, 16 November 2001: the International society of drug bulletins (ISDB) defines what is a truly innovative drug

p.31

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