english.prescrire.org > Prescrire International > N°87 - February 2007

n°87

February 2007

Issue Contents
Editorial

Free  Getting back on the right track

p.2
Balancing BigPharma influence

Marketing Authorisations

Rotavirus vaccines (rotavirus infection) (new drug)

p.3-6
One case of severe diarrhoea prevented per 100 vaccinated infants

Drotrecogin alfa (severe sepsis) (a second look)

p.7-9
More clinical trials in severe sepsis: mostly negative results

Oseltamivir (prevention of influenza in at-risk children) (new indication)

p.9-11
Vaccination is best

Free  Pramipexole (restless legs syndrome) (new indication)

p.12
Still no satisfactory treatment

Flurbiprofen lozenges (acute pharyngitis) (new indication)

p.13
NSAIDs are not to be taken like sweets

Posaconazole (invasive aspergillosis)

p.14
No proven advantage, but may be a last resort for other serious mycoses

Infliximab (psoriasis)

p.14
Just an intravenous me-too

Adverse Effects

Buflomedil: still seizures and cardiac disorders

p.15

Abrupt onset of dementia with digoxin

p.15

2006 French pharmacovigilance meeting: major reports

p.15-23

Drug-induced hyperkalaemia is frequent

p.16

Anti-Alzheimer drugs: life-threatening adverse effects

p.16

Necrotising fasciitis, dermal infections and NSAIDs: caution!

p.17

Carbocisteine: frequent cutaneous adverse effects

p.17

Oxcarbazepine: hyponatraemia and skin reactions

p.18

Voriconazole: serious adverse effects and interactions

p.18

Metformin: preventable lactic acidosis

p.19

Adverse drug reactions during heatwaves

p.19

Reversible erythromycin ototoxicity

p.20

Imatinib: cancer-causing?

p.20

TNF-alpha antagonists: pulmonary legionellosis

p.20

Fixed pigmented erythema due to sulfamethoxazole-trimethoprim

p.21

Cutaneous adverse effects of angiotensin-II receptor antagonists

p.21

Tamoxifen and hypertriglyceridaemia

p.21

Drug-induced male infertility

p.22

Cataracts on inhaled steroids

p.22

Exposure to interferon during pregnancy

p.22

No NSAIDs during pregnancy

p.22

Poor physician and pharmacist awareness of drug-related risks during pregnancy

p.23

Reviews

Alcohol withdrawal syndrome. How to predict, prevent, diagnose and treat it

p.24-31

Prescrire's proposals

p.30
Alcohol withdrawal syndrome: how to predict, prevent, diagnose and treat it

Outlook

Free  BigPharma

p.32-33
Sophisticated advertising

Free  BigPharma

p.33-35
An alliance of organisations is combatting an EU project

Free  Read and pass along the joint declaration

p.34

Free  Drugs for rare diseases: Mixed assessment in Europe

p.36-42

Prescrire puts patients' needs first

p.44

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