english.prescrire.org > Prescrire International > N°92 - December 2007

n°92

December 2007

Issue Contents
Editorial

Free  Shocking market approval

p.222
Unethical trials and reckless doctors

Marketing Authorisations

Etoricoxib (joint pain) (new drug)

p.223-227
Avoid cox-2 inhibitors for pain

Arterial thrombosis and NSAIDs

p.225

Exenatide (type 2 diabetes) (new drug)

p.228-231
For some overweight patients

The different classes of antidiabetic drugs

p.229

Buprenorphine + naloxone (opioid dependence) (new combination)

p.232-235
No proof of reduced risk of self-administered injection

Nebivolol (heart failure) (new indication)

p.235
Me-too available in single dose strength only

Paliperidone (schizophrenia) (new drug)

p.236-237
Just a metabolite of risperidone

Clofarabine (acute lymphoblastic leukaemia in children) (new drug)

p.238-239
A last resort

Alglucosidase alfa (Pompe disease) (new drug)

p.240-241
A short-term benefit

Intra-articular triamcinolone (juvenile idiopathic arthritis) (new indication)

p.242
Several months of relief

Leuprorelin, triptorelin (locally advanced prostate cancer) (new indications)

p.243
Minimally assessed me-toos

Ibuprofen (migraine attacks) (new indication)

p.244
Don't begin with 400 mg

Common stems - INNs -amivir and -arabine

p.244

Common stems - INNs -amivir and -arabine

p.244

Tigecycline

p.245
Complicated cutaneous and intra-abdominal infections: no progress

Daptomycin

p.245
Severe gram-positive infections: no advantage, but risk of muscle disorders

Adverse Effects

Free  Aluminium-containing transdermal patches: a risk of burn

p.246

Peripheral neuropathy and statins

p.247-248

Levonorgestrel-releasing intrauterine device and uterine perforation

p.248-249

Topical tacrolimus plus oral alcohol: skin irritation

p.249

Topical tacrolimus and risk of cancer

p.250

Rimonabant: suicide and depression

p.250-251

LMWH and renal failure: bleeding

p.251

Glatiramer: cutaneous necrosis

p.251

Reviews

Multiple sclerosis. Interferon beta for some serious forms

p.252-257
Interferon beta for some serious forms

Interferon beta: a burdensome treatment

p.255

COPD: don't use fluticasone + salmeterol

p.257-258
Increased susceptibility to pneumonia

Elderly patients with dementia: towards less neuroleptic use

p.258
Behavioural management can help

Diabetes prevention: still no effective drugs

p.258
No preventive effect for ramipril and cardiac adverse effects for rosiglitazone

Outlook

Free  WHO: do as we say, not as we do...

p.259-260

Nutritional health warnings: just for show

p.261

Treatment compliance: more complex than it seems

p.262

A professional training organisation

p.264

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