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n°92

December 2007

Prescrire International

Issue Contents

Editorial
Free Shocking market approval	p.222
Unethical trials and reckless doctors

Marketing Authorisations
Etoricoxib (joint pain) (new drug)	p.223-227
Avoid cox-2 inhibitors for pain


Arterial thrombosis and NSAIDs	p.225


Exenatide (type 2 diabetes) (new drug)	p.228-231
For some overweight patients


The different classes of antidiabetic drugs	p.229


Buprenorphine + naloxone (opioid dependence) (new combination)	p.232-235
No proof of reduced risk of self-administered injection


Nebivolol (heart failure) (new indication)	p.235
Me-too available in single dose strength only


Paliperidone (schizophrenia) (new drug)	p.236-237
Just a metabolite of risperidone


Clofarabine (acute lymphoblastic leukaemia in children) (new drug)	p.238-239
A last resort


Alglucosidase alfa (Pompe disease) (new drug)	p.240-241
A short-term benefit


Intra-articular triamcinolone (juvenile idiopathic arthritis) (new indication)	p.242
Several months of relief


Leuprorelin, triptorelin (locally advanced prostate cancer) (new indications)	p.243
Minimally assessed me-toos


Ibuprofen (migraine attacks) (new indication)	p.244
Don't begin with 400 mg


Common stems - INNs -amivir and -arabine	p.244


Common stems - INNs -amivir and -arabine	p.244


Tigecycline	p.245
Complicated cutaneous and intra-abdominal infections: no progress


Daptomycin	p.245
Severe gram-positive infections: no advantage, but risk of muscle disorders

Adverse Effects
Free Aluminium-containing transdermal patches: a risk of burn	p.246


Peripheral neuropathy and statins	p.247-248


Levonorgestrel-releasing intrauterine device and uterine perforation	p.248-249


Topical tacrolimus plus oral alcohol: skin irritation	p.249


Topical tacrolimus and risk of cancer	p.250


Rimonabant: suicide and depression	p.250-251


LMWH and renal failure: bleeding	p.251


Glatiramer: cutaneous necrosis	p.251

Reviews
Multiple sclerosis. Interferon beta for some serious forms	p.252-257
Interferon beta for some serious forms


Interferon beta: a burdensome treatment	p.255


COPD: don't use fluticasone + salmeterol	p.257-258
Increased susceptibility to pneumonia


Elderly patients with dementia: towards less neuroleptic use	p.258
Behavioural management can help


Diabetes prevention: still no effective drugs	p.258
No preventive effect for ramipril and cardiac adverse effects for rosiglitazone

Outlook
Free WHO: do as we say, not as we do...	p.259-260


Nutritional health warnings: just for show	p.261


Treatment compliance: more complex than it seems	p.262


A professional training organisation	p.264

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