english.prescrire.org > Prescrire International > N°96 - August 2008

n°96

August 2008

Issue Contents
Editorial

Free  The constant practitioner

p.134
Resist the urge to overmedicate

Marketing Authorisations

Raltegravir (in multidrug-resistant HIV) (new drug)

p.135-137
Alternative to enfuvirtide/darunavir

Free  Adalimumab (severe Crohn's disease) (new indication)

p.137
A second TNF alpha antagonist

Metformin (dispersible tablets) (line extension)

p.138
A welcome formulation

Solostar° pen for glargine and glulisine insulins (line extension)

p.138-139
Less convenient than Innolet° pen

Inhaled insulin no longer marketed (discontinuation)

p.139
Welcome news

Inhaled insulin and lung cancer

p.139

Kaletra° oral solution (packaging)

p.140
Modification of confusing label

Zanamivir (in children over 5 years) (new indication)

p.141
Influenza in children and adults: symptom relief or vaccination

INN common stems: -tegravir

p.141

Free  Daily tadalafil (line extension)

p.142
Beware medicalisation of human existence

Zoledronic acid (postmenopausal osteoporosis) (new indication)

p.143
No therapeutic advantage

Betamethasone plaster (new drug)

p.144
Just a useless gadget

Infliximab (severe Crohn's disease in children) (new indication)

p.145
Many unknowns

Fentanyl by iontophoresis (postoperative analgesia) (new drug)

p.146-149
A step backwards compared with intravenous morphine

Rufinamide

p.149
Further evaluation is needed in Lennox-Gastaut syndrome

Dasatinib

p.149-150
For some difficult cases of adult leukaemia

Carbetocin

p.150
A synthetic oxytocin analogue with no clear advantages

Adverse Effects

Colchicine: serious interactions

p.151-153

Death due to intrathecal vindesine

p.153

Isotretinoin and intestinal damage

p.154-156

Isotretinoin affects all mucous membranes

p.155

SSRI antidepressants and persistent pulmonary hypertension in newborns

p.156

Iatrogenic burns: beware of microwaves!

p.157-158

Atrial-oesophageal fistula after radiofrequency ablation

p.158

Cancer chemotherapy: sometimes takes the pleasure out of eating

p.159-160

Clozapine: ileus

p.160

HPV 6, 11, 16, 18 vaccine: pharmacovigilance reports in 2007

p.160

Benzalkonium chloride: death of an asthmatic patient

p.160

Bisphophonates and atrial fibrillation

p.161

Cysteamine: Ehlers-Danlos syndrome

p.161

Confusion and stroke due to an “umbrella brand” product

p.161

Reviews

Artemisinin derivatives and malaria

p.162-168

Types of artemisinin derivatives

p.164

Prescrire's advice: Treatment of uncomplicated malaria attacks

p.167

Intravenous artesunate for severe malaria

p.168-170
An alternative to intravenous quinine

Treatment of facial lipoatrophy in HIV-infected patients

p.170
Switching drugs, surgery or polylactic acid

Outlook

Free  Editorial Distinguishing between research and clinical care

p.171

Access Artemisinin in Africa

p.172

Prevention Waterpipe smoking: risky, but increasingly popular

p.173

©Prescrire byline reflects a unique editorial process

p.176

Forum

Forum The Advance trial and type 2 diabetes (continued)

p.173-174

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