english.prescrire.org > Prescrire International > N°226 - May 2021

n°226

May 2021

Issue Contents
Editorial

Free  Orphan drugs: amendment needed

p.115

Marketing Authorisations

Gilteritinib (Xospata°) and acute leukaemia with a FLT3 gene mutation

p.117
An additional option for relapsed or refractory leukaemia

Rituximab (Mabthera° or other brands) and pemphigus vulgaris

p.118-119
More patients in remission than with other immunosuppressants

INN Common stem: -orph-

p.119

Brolucizumab (Beovu°) and age-related macular degeneration

p.120

Dacomitinib (Vizimpro°) and non-small cell lung cancer

p.121

Free  Ciclosporin eye drops (Verkazia°) in severe vernal keratoconjunctivitis

p.122

Dupilumab (Dupixent°) and severe asthma

p.123

Ranibizumab (Lucentis°) and proliferative diabetic retinopathy

p.123

Adverse Effects

Cabergoline in hyperprolactinaemia: valvulopathy

p.124

Progestogens in utero: psychiatric disorders?

p.125

Clopidogrel + rifampicin: bleeding

p.126

Fluoroquinolones: valvulopathy

p.126

Levetiracetam: aggressive behaviour

p.127

Ticagrelor: bradyarrhythmias and ventricular pauses

p.127

Reviews

Medical cannabis in chronic pain

p.128-132
An option for some types of pain, while awaiting further evaluation

Bortezomib as part of first-line treatment for certain types of multiple myeloma

p.132-133

Daratumumab (Darzalex°) as part of first-line treatment for certain types of multiple myeloma

p.133

Queries and Comments. Baclofen for alcohol dependence: what is the evidence of efficacy?

p.134-135

Outlook

Efficacy of antidepressants: overestimated by a succession of biases related to the reporting of trial results

p.136-137

Medtronic, a company embedded in hospitals

p.137-138

Free  Beware of "spin" in clinical trials

p.139

Masthead

Free  Masthead

p.114

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