english.prescrire.org > Prescrire International > N°231 - November 2021

n°231

November 2021

Issue Contents
Editorial

Free  Words and numbers

p.255

Marketing Authorisations


Onasemnogene abeparvovec (Zolgensma°) in spinal muscular atrophy

p.257-258
Results that encourage continued evaluation

Editors' opinion. Acknowledging uncertainty

p.258

Covid-19 vaccine booster dose: great uncertainty over its value in the general population

p.258

Docetaxel (Taxotere° or other brands) and metastatic hormone-sensitive prostate cancer

p.259-260

Avapritinib (Ayvakyt°) and certain gastro­intestinal stromal tumours

p.260-261
Very weak data suggesting longer survival

INN Common stem: -fungin

p.261

Imipenem + cilastatin + relebactam (Recarbrio°) and serious infections

p.262-263

Nintedanib (Ofev°) in systemic sclerosis-associated interstitial lung disease

p.263

Adverse Effects


Known adverse effects of messenger RNA covid-19 vaccines as of mid-2021

p.264-265

Erenumab: hyper­­tension

p.266

Beta-blocker eye drops + verapamil: brady­cardia and collapse

p.266-267

Vasoconstrictor decongestants: ischaemic optic neuropathy

p.267

Free  Growth hormone: cardio­vascular events in young adults

p.268

Free  Thiazide diuretics: choroidal effusion and acute myo­­pia

p.268

Tramadol: hyper­­acusis

p.269

Prolonged treatment with topical or inhaled corticosteroids: osteoporotic fractures

p.269-270

Asthma and COPD: risk of confusion of the brand name of the drug with that of the inhaler

p.270

Reviews


Preventing the cardio­­vascular complications of type 2 diabetes

p.271
No advance with ertugliflozin

Canagliflozin and type 2 diabetes with nephr­o­pathy

p.271-272
As many risks as benefits?

Dapagliflozin and renal failure

p.272-273
Further evaluation needed

Outlook


Medical devices that resemble medicines: benefits for industry, uncertainties for patients

p.274-275

Ulipristal 5 mg (Esmya°) for uterine fibroids: authorisation reinstated in the EU

p.276

Free  Consultants on anything and everything

p.277

Accelerated marketing authorisation: many of the drugs approved do not have high therapeutic value

p.278

Book review. "Malignant: How Bad Policy and Bad Evidence Harm People with Cancer"

p.279

Masthead


Free  Masthead

p.254

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