english.prescrire.org > Prescrire International > N°243 - December 2022

n°243

December 2022

Issue Contents
Editorial

Free  Europe and medicines

p.283

Marketing Authorisations


Dapivirine vaginal ring in the prevention of HIV

p.285-288
An uncompelling evaluation and uncertain level of efficacy

Pemigatinib (Pemazyre°) in certain cholangiocarcinomas

p.288

Atidarsagene autotemcel (Libmeldy°) in metachromatic leukodystrophy

p.289-290
For children under 7 years of age, especially before the onset of symptoms

Nivolumab (Opdivo°) as adjuvant treatment for certain oesophageal cancers

p.290

Editors' opinion. Insist upon it

p.291

Buprenorphine as subcutaneous implants (Sixmo°) for opioid dependence

p.291

Pembrolizumab (Keytruda°) as first-line treatment for certain advanced oesophageal cancers

p.292-293

Venetoclax (Venclyxto°) as first-line treatment for acute myeloid leukaemia

p.293

Brivaracetam (Briviact°) for focal epilepsy from 2 years of age

p.294

Idecabtagene vicleucel (Abecma°) in multiple myeloma after failure of several lines of treatment

p.294

Caplacizumab (Cablivi°) and acquired thrombotic thrombocytopenic purpura in adolescents

p.295

Adverse Effects


Opioids: endocrine disruptors

p.296-298

Tramadol: excess mortality compared with codeine?

p.299

NSAIDs in children: acute kidney injury

p.299

Metopimazine, domperidone, metoclopramide: ischaemic stroke

p.300

Methotrexate + cotrimoxazole: severe pancytopenia

p.300

Donepezil: QT interval prolongation

p.301

Common stem: -azosin

p.301

Outlook


Free  Impending changes to European pharmaceutical regulations

p.302-304
Part I. Civil society's analysis of the Commission's proposals: major changes ahead, improvements needed

Leeza Osipenko: "up to us to build a different system"

p.305-306

Reports of fatal outcomes recorded with covid-19 vaccines

p.306-307

Masthead


Free  Masthead

p.282

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