english.prescrire.org > Prescrire International > N°248 - May 2023

n°248

May 2023

Issue Contents
Editorial

Free  A difficult choice

p.115

Marketing Authorisations


Anifrolumab (Saphnelo°) in systemic lupus erythematosus after failure of standard therapy

p.117-119
Avoid burdening patients with an additional treatment whose clinical efficacy has not been adequately demonstrated

Selumetinib (Koselugo°) in plexiform neuro­fibromas due to neuro­fibromatosis type 1

p.120-122
Often a reduction in tumour size, but without evidence of clinical improvement

Filgotinib (Jyseleca°) in ulcerative colitis

p.122

Sotorasib (Lumykras°) in non-small cell lung cancer with KRAS G12C mutation

p.123-124

Dabigatran (Pradaxa°) for venous thrombo­­sis in children and adolescents

p.124-125

Degarelix (Firmagon°) in localised or locally advanced prostate cancer

p.125

Mepolizumab (Nucala°) in eosinophilic granulomatosis with polyangiitis

p.126-127

Mepolizumab (Nucala°) in certain patients with hypereosinophilic syndrome

p.127

Tafasitamab (Minjuvi°) in relapsed or refractory diffuse large B-cell lymphoma

p.128

Blinatumomab (Blincyto°) for first relapse of acute lymphoblastic leukaemia in children

p.129

Chlormadinone, nomegestrol: risk of meningioma added to the SmPCs for contraceptive products

p.130

Adverse Effects


Janus kinase inhibitors: higher incidence of serious adverse effects and death than with TNF-alpha inhibitors

p.131

Dutasteride, finasteride: high-grade prostate cancer (continued)

p.132-133

Ondansetron: blindness, often transient

p.133-134

Beta-blockers in eye drops: serious bronchospasm still occurring

p.134

Doxylamine: dependence

p.134-135

Zinc or other di- or trivalent cations and bictegravir: virological failure

p.135

Common stem: -ac

p.135

Outlook


Early and compassionate access to drugs in France

p.136-137

Clinical trials in children: many results go unreported

p.137

Better prevention of the harms of drugs during pregnancy

p.138

Lack of evidence that "orphan" drugs are a therapeutic advance

p.138-139

Tramadol and codeine: patients unaware of the risks

p.139

Masthead


Free  Masthead

p.114

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