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The Prescrire Awards for 2012

The 2012 Prescrire Awards: a yearly round-up from the editors of independent French journal Prescrire

The Prescrire Drug Awards for 2012

Products evaluated during the previous year in the New Products section of our French edition are eligible for the Prescrire Awards for new drugs and indications (in 2012: issues 339 to 350).

See also Prescrire's annual review of new drugs:
L'année 2012 du médicament : progrès en berne,
mesures timides pour la protection des patients

Rev Prescrire 2013 ; 33 (352) : 134-137.
> Pdf (in French), free


PILULE D'OR / GOLDEN PILL AWARD
Prescrire's "Pilule d'Or" ("Golden Pill") award recognises drugs that provide a major therapeutic advance for patients and healthcare professionals in a field in which no treatment was previously available. No "Golden Pill" was awarded for 2012.
 HONOURS LIST
No drugs were added to the Honours List for 2012. The List recognises drugs which provide a clear advantage for some patients in comparison to existing therapeutic options, albeit with certain limitations.
NOTEWORTHY
The following drugs provided a modest improvement in patient care.
abiraterone
ZYTIGA°
tablets
Janssen-Cilag 
Metastatic prostate cancer following failure of castration and chemotherapy; in combination with a corticosteroid (Prescrire Int n° 128)
boceprevir
VICTRELIS°
capsules
Merck Sharp & Dohme
Chronic hepatitis C due to a genotype 1 virus, previously untreated or after failure of the peginterferon alfa + ribavirin combination (Prescrire Int n° 126)

 

About the 2012 Prescrire Drug Awards
Each month, the Prescrire Editorial Staff presents systematic and comparative analyses of available data on all newly approved drugs in France, and on new therapeutic indications granted for existing drugs. The goal is to help readers to distinguish, among the plethora of lavishly promoted commercial products, those medications worth adding to their prescribing lists or worth using instead of existing products; also to distinguish which products are to be avoided.

This evaluation is based on rigorous procedures that include a thorough literature search, a large panel of reviewers (specific to each project) and a quality control system to verify that the text is consistent with the data in the references. Full details > HERE

Total independence
This work is carried out by the Editorial Staff in total independence. Prescrire is financed exclusively by subscribers. Neither the French nor the English edition carries any paid advertising, nor do we receive grants or subsidies of any kind (see our annual financial report in the June issue of Prescrire International). At the end of each year, the Prescrire Drug Awards are based on the review articles published in the French edition in that year, and take into account any new data available since the initial articles were published.

> Click here to download the rules governing the Prescrire Awards (pdf, in French)

"Therapeutic advance" is defined as better efficacy, fewer or less severe adverse effects (for similar efficacy), or safer or more convenient administration.

2012: two minor advances
Once again, the Golden Pill Award was not attributed this year (see above). In addition, no new drugs and no new indications for existing drugs were deemed worthy of inscription on the Honours List for 2012.

Two new drugs marketed in 2012 provided a slight advantage for certain patients.

Abiraterone is an antiandrogen with a mechanism of action different from that of cyproterone. A good-quality trial, in men with metastatic prostate cancer in whom androgen suppression followed by chemotherapy had failed, showed that abiraterone prolonged overall survival by about 4 months (to 15 months, versus 11 months in the placebo group). Adverse effects, including hepatic and cardiac disorders are sometimes severe but are acceptable if patients are closely monitored. It is given orally.

Boceprevir is an antiviral agent that inhibits NS3/4A serine protease (a). In patients with chronic hepatitis C due to a genotype 1 virus, who had never been treated or in whom the peginterferon alfa + ribavirin combination had failed, oral boceprevir add-on therapy increased the rate of sustained virological responses by 30% to 40%, although follow-up is too short to judge the efficacy of boceprevir on clinical outcomes (mortality, liver transplantation, cirrhosis). Its main adverse effects are potentially severe haematological disorders, which can be anticipated and possibly corrected.

A continuing lack of therapeutic advance
2012 was another disappointing year for patients and healthcare professionals, as the pharmaceutical industry failed to provide new drugs with tangible therapeutic advantages. 

©Prescrire February 2013

Note:
a- Telaprevir, un antiviral drug belonging to the same class as boceprevir, is a useful alternative to boceprevir but carries a risk of unpredictable and potentially severe cutaneous adverse reactions. This is why telaprevir did not also receive an award.

"The 2012 Prescrire Awards" Prescrire Int 2013 ; 22 (136) : 79-82. (pdf, free)