english.prescrire.org > Spotlight > Archives : 2011 > In the June issue of Prescrire International: adverse effects of fluoxetine, bevacizumab and venous sclerosants

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In the June issue of Prescrire International: adverse effects of fluoxetine, bevacizumab and venous sclerosants

FREE DOWNLOAD A page selected from the Adverse Effects section this month includes reports on these three types of drug,  demonstrating the wide variety of topics covered in Prescrire International.
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Fluoxetine in early pregnancy: cardiac birth defects (Summary)

  • Exposure to fluoxetine in the first trimester of pregnancy is associated with an increased risk of cardiac malformations in newborns.

  • Caution is advised with all selective serotonin reuptake inhibitors (SSRIs).

Bevacizumab, sunitinib: osteonecrosis of the jaw (Summary)

  • Both of these cancer drugs have been linked to osteonecrosis of the jaw.
     
  • This risk should be taken into account by avoiding invasive dental procedures whenever possible in patients who have been exposed to these drugs.

Venous sclerosants: distant ischaemic disorders (Summary)

  • A survey of ischaemic disorders linked to venous sclerosants lauromacrogol 400, sodium tetradecyl sulphate and chrome alum was examined by the French National Pharmacovigilance committee.
     
  • Disorders  included:  strokes, transient ischaemic attacks, migraine, visual disorders, cardiac disorders, pulmonary embolism, deep venous thrombosis and peripheral arterial thrombosis.

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©Prescrire 1 June 2011

Prescrire Int 2011; 20 (117) : 155. (Pdf, free)
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