english.prescrire.org > Spotlight > Archives : 2019 > Emtricitabine + tenofovir disoproxil (Truvada° and other brands) for prevention of HIV infection in adolescents

Spotlight: Archives

Every month, the subjects in Prescrire’s Spotlight.

2019 : 1 | 30 | 60

In the July-August issue of Prescrire International: emtricitabine + tenofovir disoproxil (Truvada° and other brands) for prevention of HIV infection in adolescents

FREE DOWNLOAD Based on extrapolation of the data obtained in adults, the emtricitabine + tenofovir disoproxil combination (Truvada° or other brands) appears worth offering to adolescents whose sex practices place them at particularly high risk of contracting HIV infection.
Full text available for free download.

Summary

  • In seronegative adults at risk of sexually acquired HIV infection, in particular those who engage in high-risk sexual behaviours, the emtricitabine + tenofovir disoproxil fixed-dose combination (Truvada° or other brands) markedly reduces but does not eliminate the risk of contracting HIV infection.

  • The combination has been authorised in the European Union for the prevention of HIV infection in adolescents whose sex practices place them at high risk of becoming infected.
     
  •  POSSIBLY HELPFUL  The emtricitabine + tenofovir disoproxil combination has undergone inadequate evaluation as HIV prophylaxis in adolescents. However, based on extrapolation of the data obtained in adults, this option appears worth offering to adolescents whose sex practices place them at particularly high risk of contracting HIV infection. It is important to inform them that this treatment does not provide complete protection and to stress the importance of treatment adherence. They should also be strongly encouraged to use condoms and to undergo regular screening for sexually transmitted infections, including HIV.

Full text available for free download.

 ©Prescrire 1 July 2019

"Emtricitabine + tenofovir disoproxil for prevention of HIV infection in adolescents" Prescrire Int 2019; 28 (206): 175. (Pdf, free).

Share Share on Facebook Share on Twitter

 
Share
Partager sur Facebook Partager sur Twitter

 
Download the full review
Pdf, free
Prescrire's rating:
Prescrire's rating
 POSSIBLY HELPFUL 

See also:

Emtricitabine + tenofovir
disoproxil to prevent HIV
transmission. For certain
people at high risk of
acquiring HIV infection
Prescrire Int 2017;
26 (187): 257-25.
Pdf, subscribers only

Risk-taking
Prescrire Int 2013;
22 (140): 181.
Pdf, subscribers only