english.prescrire.org > Spotlight > Archives : 2019 > Dolutegravir + rilpivirine (Juluca°) dual therapy in HIV infection

Spotlight: Archives

Every month, the subjects in Prescrire’s Spotlight.

2019 : 1 | 30 | 60

Dolutegravir + rilpivirine (Juluca°) dual therapy in HIV infection

FEATURED REVIEW First-line therapy for patients with HIV infection is usually based on triple therapy. When sustained virological suppression has been achieved, treatment "simplification" can sometimes be considered. Is the two-drug regimen dolutegravir + rilpivirine (Juluca°) any better than other treatment options?
Full review (3 pages) available for download by subscribers.

Prescrire's rating

  •  NOTHING NEW  In patients who have an undetectable viral load for at least one year and no history of HIV resistance after taking triple antiretroviral therapy, two comparative trials in a total of 1024 patients showed that switching to dolutegravir + rilpivirine dual therapy is no less effective in the short term than continuing triple therapy. However, dolutegravir + rilpivirine has not been compared with triple therapy in patients who did not tolerate a previous three-agent regimen, and the trials did not show that decreasing the number of antiretroviral drugs from 3 to 2 offered any particular clinical advantage. Combining rilpivirine with a single antiretroviral rather than two may increase the risk of resistance, especially in case of poor adherence.

©Prescrire 1 November 2019

"Dolutegravir + rilpivirine (Juluca°) dual therapy in HIV infection. Risk of resistance to rilpivirine must be taken into account" Prescrire Int 2019; 28 (209): 257-259. (Pdf, subscribers only).

Share Share on Facebook Share on Twitter

 

Share
Partager sur Facebook Partager sur Twitter

 
Download the full review.
Pdf, subscribers only

Prescrire's rating:
Prescrire's rating
  NOTHING NEW 

See also:

Additional texts available
via the Search function,
using the keyword "HIV"
Search